发现一系列芳基-N-(3-(烷基氨基)-5-(三氟甲基)苯基)苯甲酰胺类作为 TRPA1 拮抗剂。
Discovery of a series of aryl-N-(3-(alkylamino)-5-(trifluoromethyl)phenyl)benzamides as TRPA1 antagonists.
机构信息
AstraZeneca/OmegaChem, Department of Medicinal Chemistry, Montréal H4S 1Z9, Canada.
AstraZeneca, DMPK, Montréal H4S 1Z9, Canada.
出版信息
Bioorg Med Chem Lett. 2014 Jul 15;24(14):3204-6. doi: 10.1016/j.bmcl.2014.05.013. Epub 2014 May 16.
PMID:24880903
Abstract
We describe the discovery and advancement of a novel series of TRPA1 antagonist having an aryl-N-(3-(alkylamino)-5-(trifluoromethyl)phenyl)benzamide scaffold. The physical and in vitro DMPK profiles are discussed.
摘要
我们描述了一种新型的 TRPA1 拮抗剂的发现和进展，该拮抗剂具有芳基-N-(3-(烷基氨基)-5-(三氟甲基)苯基)苯甲酰胺骨架。讨论了其物理和体外 DMPK 特性。
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