Flammiger Anna, Bacher Ulrike, Christopeit Maximilian, Horn Christiane, Rühlmann Elke, Kluge Katrin, Vettorazzi Eik, Bokemeyer Carsten, Binder Mascha
Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumorzentrum (University Comprehensive Cancer Center Hamburg), University Medical Center Hamburg-Eppendorf , Hamburg , Germany.
Leuk Lymphoma. 2015 Mar;56(3):639-44. doi: 10.3109/10428194.2014.926347. Epub 2014 Aug 4.
Immunophenotypic distinction between neoplastic and reactive T-cell clones can be challenging, as peripheral T-cell lymphomas (PTCLs) lack an immunophenotypic marker of clonality. Systematic screening of 10,510 cases analyzed by immunophenotyping at our institution between 2006 and 2012 resulted in 49 cases with aberrant T-cell populations of unclear significance. Review of patient charts allowed us to assign these cases to three categories. In 21 cases, PTCL could later be confirmed by complementary diagnostics (PTCL group). In 20 cases, follow-up confirmed the reactive nature of the aberrant T-cells (non-PTCL group). Eight cases remained of unclear significance. Neither the population size nor the number of aberrant markers differed significantly between the PTCL and non-PTCL groups. Only loss of CD7 was found significantly more often in patients with PTCL than in patients with non-PTCL (p = 0.037). Our data show that aberrant T-cell populations need to be interpreted in the clinicopathological context, as reactive and neoplastic phenotypes largely overlap.
肿瘤性和反应性T细胞克隆之间的免疫表型区分可能具有挑战性，因为外周T细胞淋巴瘤（PTCL）缺乏克隆性的免疫表型标志物。2006年至2012年间，对我院10510例进行免疫表型分析的病例进行系统筛查，结果发现49例T细胞群异常但意义不明。查阅患者病历后，我们将这些病例分为三类。在21例中，PTCL后来可通过补充诊断得到证实（PTCL组）。在20例中，随访证实异常T细胞具有反应性（非PTCL组）。8例意义仍不明确。PTCL组和非PTCL组之间的细胞群大小和异常标志物数量均无显著差异。仅发现PTCL患者中CD7缺失的情况明显多于非PTCL患者（p = 0.037）。我们的数据表明，异常T细胞群需要在临床病理背景下进行解读，因为反应性和肿瘤性表型在很大程度上重叠。
