Li J-J, Xie D
Center for Cancer Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China.
Oncogene. 2015 Apr 9;34(15):1890-8. doi: 10.1038/onc.2014.127. Epub 2014 Jun 2.
RACK1 is a highly conserved intracellular adaptor protein with significant homology to Gβ and was originally identified as the anchoring protein for activated protein kinase C. In the past 20 years, the number of binding partners and validated cellular functions for RACK1 has increased, which facilitates clarification of its involvement in different biological events. In this review, we will focus on its role in cancer, summarizing its aberrant expression, pro- or anti-oncogenic effects and the underlying mechanisms in various cancers.
RACK1是一种高度保守的细胞内衔接蛋白，与Gβ具有显著同源性，最初被鉴定为活化蛋白激酶C的锚定蛋白。在过去20年中，RACK1的结合伴侣数量和已证实的细胞功能有所增加，这有助于阐明其在不同生物学事件中的作用。在本综述中，我们将重点关注其在癌症中的作用，总结其在各种癌症中的异常表达、促癌或抑癌作用及潜在机制。
