A fluorescent probe for imaging symmetric and asymmetric cell division in neurosphere formation.

作者信息

Yun Seong-Wook, Leong Cheryl, Bi Xuezhi, Ha Hyung-Ho, Yu Yuan Hong, Tan Yee Ling, Narayanan Gunaseelan, Sankaran Shvetha, Kim Jun-Young, Hariharan Srivats, Ahmed Sohail, Chang Young-Tae

机构信息

Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore.

出版信息

Chem Commun (Camb). 2014 Jul 18;50(56):7492-4. doi: 10.1039/c4cc02974g.

DOI:10.1039/c4cc02974g

PMID:24882713

Abstract

We report here a novel fluorescent chemical probe which stains distinct neural stem/progenitor cells (NSPCs) by binding to acid ceramidase in mouse neurospheres. is distributed evenly or unevenly to the daughter cells during multiple mitoses enabling the live imaging of symmetric and asymmetric divisions of isolated NSPCs.

摘要