Furubayashi Nobuki, Negishi Takahito, Hirata Yu, Taguchi Kenichi, Nakamura Motonobu
Department of Urology, National Kyushu Cancer Center, Fukuoka, Japan.
Department of Pathology, National Kyushu Cancer Center, Fukuoka, Japan.
J Clin Med Res. 2014 Aug;6(4):302-4. doi: 10.14740/jocmr1850w. Epub 2014 May 22.
Although sunitinib is associated with a variety of adverse events, cases of sunitinib-related acute cholecystitis have rarely been reported. We herein report two cases of sunitinib-related acute acalculous cholecystitis in patients with clear cell renal cell carcinoma. In both cases, the gallbladder was surgically removed because it was difficult to improve the patient's condition with the cessation of sunitinib and non-surgical treatment only. Attention must be paid to the possibility of sunitinib-related acute cholecystitis, which, although uncommon, can be life-threatening.
虽然舒尼替尼与多种不良事件相关，但舒尼替尼相关的急性胆囊炎病例鲜有报道。我们在此报告两例透明细胞肾细胞癌患者发生的舒尼替尼相关的急性非结石性胆囊炎。在这两例病例中，由于仅停用舒尼替尼和非手术治疗难以改善患者病情，故均对胆囊进行了手术切除。必须注意舒尼替尼相关急性胆囊炎的可能性，这种情况虽然不常见，但可能危及生命。
