登革病毒感染中的免疫发病机制与保护作用
Immunopathogenesis Versus Protection in Dengue Virus Infections.
作者信息
Rothman Alan L, Medin Carey L, Friberg Heather, Currier Jeffrey R
机构信息
Institute for Immunology and Informatics, College of the Environment and Life Sciences, University of Rhode Island, 80 Washington Street, Providence, RI 02903; Phone +1-401-277-5419; FAX +1-401-277-5244.
Viral Diseases Branch, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD; Phone +1-301-319-9224; FAX +1-301-319-9661.
出版信息
Curr Trop Med Rep. 2014 Mar 1;1(1):13-20. doi: 10.1007/s40475-013-0009-0.
Abstract
Dengue viruses (DENV) are mosquito-borne viruses that cause significant morbidity. The existence of four serotypes of DENV with partial immunologic cross-reactivity creates the opportunity for individuals to experience multiple acute DENV infections over the course of their lifetimes. Research over the past several years has revealed complex interactions between DENV and the human innate and adaptive immune systems that can have either beneficial or detrimental influences on the outcome of infection. Further studies that seek to distinguish protective from pathological immune responses in the context of natural DENV infection as well as clinical trials of candidate DENV vaccines have an important place in efforts to control the global impact of this re-emerging viral disease.
摘要
登革病毒（DENV）是通过蚊子传播的病毒，可导致严重发病。DENV有四种血清型，它们具有部分免疫交叉反应性，这使得个体有可能在一生中经历多次急性DENV感染。过去几年的研究揭示了DENV与人类固有免疫系统和适应性免疫系统之间的复杂相互作用，这些相互作用可能对感染结果产生有益或有害的影响。在自然DENV感染的背景下，进一步区分保护性免疫反应和病理性免疫反应的研究，以及候选DENV疫苗的临床试验，对于控制这种重新出现的病毒性疾病的全球影响具有重要意义。
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