Modica M A, Freddi S, Caruso C
Servizio di Immunologia Tissutale, Istituto di Patologia generale della Università di Palermo, Italia.
Exp Clin Immunogenet. 1989;6(4):251-7.
In the present study we have investigated the HLA-B8,DR3-associated control of serum IgA levels in 110 randomly selected HLA-typed healthy subjects. Serum IgG, IgA, IgM and IgE levels were measured in all individuals. The values were analyzed according to age, sex and HLA-DR phenotype. No correlation between age and serum IgA, IgM and IgE levels was found in our homogeneous sample, since all subjects studied were in a narrow age range, i.e. 20-49 years. In contrast, a significant positive correlation was found for IgG levels. The mean IgM level was significantly higher in females than in males, whereas the mean IgA and IgE levels were significantly lower in females. HLA-DR2-positive subjects displayed the significantly highest levels of serum IgE, whereas HLA-B8,DR3-positive subjects showed the significantly lowest levels of serum IgA. Thus, our results show that in our random sample sex and DR phenotype are involved in the control of serum IgA, IgM and IgE levels. The genetic control of sex and HLA-B8,DR3 of serum IgA levels could be related to the high incidence of autoimmune disorders among females and HLA-B8,DR3-positive individuals. The results showing higher levels of IgE in HLA-DR2-positive subjects might be consistent with the observation of a strong association between HLA-DR2 and IgE immune hyperresponsiveness to some allergen(s).
在本研究中，我们调查了110名随机选择的经HLA分型的健康受试者中与HLA - B8、DR3相关的血清IgA水平控制情况。对所有个体测量了血清IgG、IgA、IgM和IgE水平。根据年龄、性别和HLA - DR表型对这些值进行了分析。在我们的同质样本中，未发现年龄与血清IgA、IgM和IgE水平之间存在相关性，因为所有研究对象的年龄范围较窄，即20 - 49岁。相比之下，发现IgG水平存在显著正相关。女性的平均IgM水平显著高于男性，而女性的平均IgA和IgE水平显著低于男性。HLA - DR2阳性受试者的血清IgE水平显著最高，而HLA - B8、DR3阳性受试者的血清IgA水平显著最低。因此，我们的结果表明，在我们的随机样本中，性别和DR表型参与了血清IgA、IgM和IgE水平的控制。血清IgA水平的性别和HLA - B8、DR3的遗传控制可能与女性和HLA - B8、DR3阳性个体自身免疫性疾病的高发病率有关。HLA - DR2阳性受试者中IgE水平较高的结果可能与观察到的HLA - DR2与对某些过敏原的IgE免疫高反应性之间的强关联一致。
