Toni Zhong, Christine B. Novak, David R. McCready, Stefan O.P. Hofer, and Jonathon C. Irish, University Health Network; Bret A. Beber, Women's College Hospital; Nancy N. Baxter, St Michael's Hospital; Toni Zhong, Jennica Platt, Brett A. Beber, Christine B. Novak, David R. McCready, Stefan O.P. Hofer, Jonathon C. Irish, and Nancy N. Baxter, University of Toronto; Kimberly A. Fernandes, Refik Saskin, Rinku Sutradhar, and Nancy N. Baxter, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
J Clin Oncol. 2014 Jul 10;32(20):2133-41. doi: 10.1200/JCO.2013.53.0774. Epub 2014 Jun 2.
To describe the population-based rates of immediate breast reconstruction (IBR) for all women undergoing mastectomy for treatment or prophylaxis of breast cancer in the past decade, and to evaluate geographic, institutional, and patient factors that influence use in the publically funded Canadian health care system.
This population-based retrospective cohort study used administrative data that included 28,176 women who underwent mastectomy (25,141 mastectomy alone and 3,035 IBR) between April 1, 2002, and March 31, 2012, in Ontario, Canada. We evaluated factors associated with IBR by using a multivariable logistic regression model with the generalized estimating equation approach.
The population-based, age-adjusted IBR rate increased from 5.1 procedures to 8.7 in 100,000 adult women (43.7%; P < .001), and the increase was greatest for prophylactic mastectomy or therapeutic mastectomy for in situ breast cancer (78.6%; P < .001). Women who lived in neighborhoods with higher median income had significantly increased odds of IBR compared with mastectomy alone (odds ratio [OR], 1.71; 95% CI, 1.47 to 2.00), and immigrant women had significantly lower odds (OR, 0.59; 95% CI, 0.44 to 0.78). A patient had nearly twice the odds of receiving IBR when she was treated at a teaching hospital (OR, 1.84; 95% CI, 1.1 to 3.06) or at a hospital with two or more available plastic surgeons (OR, 2.01; 95% CI, 1.53 to 2.65). Patients who received IBR traveled significantly farther compared with those who received mastectomy alone (OR, 1.04; 95% CI, 1.02 to 1.05 for every 10 km increase).
IBR is available to select patients with favorable clinical and demographic characteristics who travel farther to undergo surgery at teaching hospitals with two or more available plastic surgeons.
描述过去十年中所有因乳腺癌治疗或预防而行乳房切除术的女性中即刻乳房重建(IBR)的基于人群的发生率,并评估影响公共资助的加拿大卫生保健系统中IBR 使用的地理、机构和患者因素。
这项基于人群的回顾性队列研究使用了包括 28176 名女性的数据,这些女性在 2002 年 4 月 1 日至 2012 年 3 月 31 日期间在安大略省接受了乳房切除术(25141 例单纯乳房切除术和 3035 例 IBR)。我们使用广义估计方程方法的多变量逻辑回归模型评估了与 IBR 相关的因素。
基于人群的、年龄调整后的 IBR 发生率从每 10 万人中 5.1 例增加到 8.7 例(43.7%;P<0.001),预防性乳房切除术或原位乳腺癌的治疗性乳房切除术的增幅最大(78.6%;P<0.001)。居住在中位数收入较高的社区的女性与单纯乳房切除术相比,IBR 的可能性显著增加(比值比[OR],1.71;95%置信区间[CI],1.47 至 2.00),而移民女性的可能性显著降低(OR,0.59;95%CI,0.44 至 0.78)。当患者在教学医院(OR,1.84;95%CI,1.1 至 3.06)或有 2 名或更多可用整形外科医生的医院(OR,2.01;95%CI,1.53 至 2.65)接受治疗时,接受 IBR 的可能性几乎是接受单纯乳房切除术的两倍。与接受单纯乳房切除术的患者相比,接受 IBR 的患者的旅行距离明显更长(每增加 10 公里,OR 为 1.04;95%CI,1.02 至 1.05)。
IBR 可用于选择具有有利临床和人口统计学特征的患者,这些患者更远地前往拥有 2 名或更多可用整形外科医生的教学医院接受手术。