神经胶质前体细胞作为胶质瘤转化的靶点。
Glial progenitors as targets for transformation in glioma.
作者信息
Ilkhanizadeh Shirin, Lau Jasmine, Huang Miller, Foster Daniel J, Wong Robyn, Frantz Aaron, Wang Susan, Weiss William A, Persson Anders I
机构信息
Department of Neurology, University of California, San Francisco, California, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA.
Department of Neurology, University of California, San Francisco, California, USA; Department of Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, California, USA; Sandler Neurosciences Center, University of California, San Francisco, California, USA.
出版信息
Adv Cancer Res. 2014;121:1-65. doi: 10.1016/B978-0-12-800249-0.00001-9.
Glioma is the most common primary malignant brain tumor and arises throughout the central nervous system. Recent focus on stem-like glioma cells has implicated neural stem cells (NSCs), a minor precursor population restricted to germinal zones, as a potential source of gliomas. In this review, we focus on the relationship between oligodendrocyte progenitor cells (OPCs), the largest population of cycling glial progenitors in the postnatal brain, and gliomagenesis. OPCs can give rise to gliomas, with signaling pathways associated with NSCs also playing key roles during OPC lineage development. Gliomas can also undergo a switch from progenitor- to stem-like phenotype after therapy, consistent with an OPC-origin even for stem-like gliomas. Future in-depth studies of OPC biology may shed light on the etiology of OPC-derived gliomas and reveal new therapeutic avenues.
胶质瘤是最常见的原发性恶性脑肿瘤，可发生于整个中枢神经系统。最近对胶质瘤干细胞样细胞的关注表明，神经干细胞（NSCs），一种局限于生发区的少量前体细胞群，可能是胶质瘤的潜在来源。在这篇综述中，我们聚焦于少突胶质前体细胞（OPCs），即出生后脑内数量最多的循环神经胶质前体细胞群，与胶质瘤发生之间的关系。OPCs可引发胶质瘤，与神经干细胞相关的信号通路在OPC谱系发育过程中也起着关键作用。胶质瘤在治疗后也可从祖细胞样表型转变为干细胞样表型，这表明即使是干细胞样胶质瘤也起源于OPCs。未来对OPC生物学的深入研究可能会揭示OPC源性胶质瘤的病因，并揭示新的治疗途径。
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