Titosky Jordan T F, Morin Chelsea M D, Suderman Jonathan D, Olfert Jason S, Finlay Warren H, Vehring Reinhard
Department of Mechanical Engineering, University of Alberta, Edmonton, AlbertaT6G 2T8, Canada.
Department of Mechanical Engineering, University of Alberta, Edmonton, AlbertaT6G 2T8, Canada.
J Pharm Sci. 2014 Jul;103(7):2116-2124. doi: 10.1002/jps.24032. Epub 2014 Jun 2.
The purpose of the study is to understand the effect of altitude on the performance of selected pressurized metered dose inhalers (pMDIs) and dry powder inhalers (DPIs). A testing apparatus that created consistent breath profiles through the Alberta Idealized Throat was designed to test five pMDIs and two DPIs at altitudes of 670, 2450, 3260, and 4300 m. Both gravimetric and chemical assays were conducted to determine the in vitro lung dose. Additionally, spray duration and shot weight for pMDIs and device resistance for DPI were measured. There was no significant change in in vitro lung dose for any of the pMDIs tested. Shot weight and spray duration were unaffected. The device resistance of the DPIs decreased with increasing altitude and was successfully modeled as a function of ambient pressure. The in vitro lung dose of both DPIs showed no significant change when operated with an inhaler pressure drop of 4 kPa, but for the Bricanyl(®) Turbuhaler(®), a significant decrease occurred when matching the volumetric inspiratory flow rate to that of the baseline altitude.
本研究的目的是了解海拔高度对选定的压力定量吸入器（pMDIs）和干粉吸入器（DPIs）性能的影响。设计了一种通过艾伯塔理想化咽喉产生一致呼吸曲线的测试装置，用于在海拔670米、2450米、3260米和4300米的高度测试五种pMDIs和两种DPIs。进行了重量分析和化学分析以确定体外肺部剂量。此外，还测量了pMDIs的喷雾持续时间和喷雾重量以及DPIs的装置阻力。在所测试的任何一种pMDIs中，体外肺部剂量均无显著变化。喷雾重量和喷雾持续时间未受影响。DPIs的装置阻力随海拔升高而降低，并成功地被模拟为环境压力的函数。当以4 kPa的吸入器压力降操作时，两种DPIs的体外肺部剂量均无显著变化，但对于布地奈德都保，当将吸气容积流速与基线海拔高度相匹配时，出现了显著下降。
