MYC与DNA复制的调控
MYC and the control of DNA replication.
作者信息
Dominguez-Sola David, Gautier Jean
机构信息
Institute for Cancer Genetics, Columbia University, New York, New York 10032.
Institute for Cancer Genetics, Columbia University, New York, New York 10032 Department of Genetics and Development, Columbia University, New York, New York 10032.
出版信息
Cold Spring Harb Perspect Med. 2014 Jun 2;4(6):a014423. doi: 10.1101/cshperspect.a014423.
Abstract
The MYC oncogene is a multifunctional protein that is aberrantly expressed in a significant fraction of tumors from diverse tissue origins. Because of its multifunctional nature, it has been difficult to delineate the exact contributions of MYC's diverse roles to tumorigenesis. Here, we review the normal role of MYC in regulating DNA replication as well as its ability to generate DNA replication stress when overexpressed. Finally, we discuss the possible mechanisms by which replication stress induced by aberrant MYC expression could contribute to genomic instability and cancer.
摘要
MYC癌基因是一种多功能蛋白，在来自不同组织起源的很大一部分肿瘤中异常表达。由于其多功能性质，很难确定MYC的多种作用对肿瘤发生的确切贡献。在这里，我们综述了MYC在调节DNA复制中的正常作用，以及其过表达时产生DNA复制应激的能力。最后，我们讨论了异常MYC表达诱导的复制应激可能导致基因组不稳定和癌症的潜在机制。
相似文献
1
MYC and the control of DNA replication.MYC与DNA复制的调控
Cold Spring Harb Perspect Med. 2014 Jun 2;4(6):a014423. doi: 10.1101/cshperspect.a014423.
2
MYC activation is a hallmark of cancer initiation and maintenance.MYC激活是癌症起始和维持的一个标志。
Cold Spring Harb Perspect Med. 2014 Jun 2;4(6):a014241. doi: 10.1101/cshperspect.a014241.
3
MYC, Metabolism, and Cancer.MYC、代谢与癌症。
Cancer Discov. 2015 Oct;5(10):1024-39. doi: 10.1158/2159-8290.CD-15-0507. Epub 2015 Sep 17.
4
Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis.Pin1 调节 c-Myc DNA 结合的动态性，从而促进靶基因调控和肿瘤发生。
Mol Cell Biol. 2013 Aug;33(15):2930-49. doi: 10.1128/MCB.01455-12. Epub 2013 May 28.
5
Transcriptional control of DNA replication licensing by Myc.Myc对DNA复制许可的转录调控。
Sci Rep. 2013 Dec 6;3:3444. doi: 10.1038/srep03444.
6
Skp2 regulates Myc protein stability and activity.Skp2调节Myc蛋白的稳定性和活性。
Mol Cell. 2003 May;11(5):1177-88. doi: 10.1016/s1097-2765(03)00173-4.
7
MYC on the path to cancer.癌基因 MYC 研究进展。
Cell. 2012 Mar 30;149(1):22-35. doi: 10.1016/j.cell.2012.03.003.
8
Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing.通过转录组测序对猪肝脏干细胞中MYC驱动的肿瘤特征进行基因表达谱分析。
World J Gastroenterol. 2015 Feb 21;21(7):2011-29. doi: 10.3748/wjg.v21.i7.2011.
9
Developmental context determines latency of MYC-induced tumorigenesis.发育背景决定了MYC诱导肿瘤发生的潜伏期。
PLoS Biol. 2004 Nov;2(11):e332. doi: 10.1371/journal.pbio.0020332. Epub 2004 Sep 28.
10
Examining Myc-Dependent Translation Changes in Cellular Homeostasis and Cancer.检测 Myc 依赖性翻译变化在细胞内稳态和癌症中的作用。
Methods Mol Biol. 2021;2318:255-266. doi: 10.1007/978-1-0716-1476-1_13.
引用本文的文献
1
PNMA1 mediates melphalam chemoresistance in retinoblastoma via promoting DNA repair.PNMA1通过促进DNA修复介导视网膜母细胞瘤对美法仑的化疗耐药性。
Sci Rep. 2025 Jul 23;15(1):26690. doi: 10.1038/s41598-025-12206-0.
2
MYC: The Guardian of Its Own Chaos.MYC：自身混乱的守护者。
Bioessays. 2025 Jul;47(7):e70010. doi: 10.1002/bies.70010. Epub 2025 Jun 9.
3
Exploiting replication stress for synthetic lethality in MYC-driven cancers.利用复制应激实现MYC驱动癌症中的合成致死效应。
Am J Cancer Res. 2025 Apr 15;15(4):1461-1479. doi: 10.62347/RTVX8866. eCollection 2025.
4
Inhibition of programmed cell death by melanoma cell subpopulations reveals mechanisms of melanoma metastasis and potential therapeutic targets.黑色素瘤细胞亚群对程序性细胞死亡的抑制揭示了黑色素瘤转移的机制和潜在治疗靶点。
Discov Oncol. 2025 Jan 20;16(1):62. doi: 10.1007/s12672-025-01789-9.
5
Excessive MYC-topoisome activity triggers acute DNA damage, MYC degradation, and replacement by a p53-topoisome.过度的 MYC-拓扑异构酶活性会引发急性 DNA 损伤、MYC 降解，并被 p53-拓扑异构酶取代。
Mol Cell. 2024 Nov 7;84(21):4059-4078.e10. doi: 10.1016/j.molcel.2024.10.006. Epub 2024 Oct 30.
6
Non-metabolic enzyme function of pyruvate kinase M2 in breast cancer.丙酮酸激酶M2在乳腺癌中的非代谢酶功能
Front Oncol. 2024 Oct 1;14:1450325. doi: 10.3389/fonc.2024.1450325. eCollection 2024.
7
promotes oncogenesis and lethal progression of prostate cancer.促进前列腺癌的致癌作用和致死性进展。
Proc Natl Acad Sci U S A. 2024 Sep 3;121(36):e2405543121. doi: 10.1073/pnas.2405543121. Epub 2024 Aug 27.
8
Emerging advances in defining the molecular and therapeutic landscape of small-cell lung cancer.小细胞肺癌分子特征和治疗靶点的新进展。
Nat Rev Clin Oncol. 2024 Aug;21(8):610-627. doi: 10.1038/s41571-024-00914-x. Epub 2024 Jul 4.
9
A microdeletion event at 19q13.43 in IDH-mutant astrocytomas is strongly correlated with MYC overexpression.19q13.43 微缺失事件与 IDH 突变型星形细胞瘤中 MYC 的过表达密切相关。
Acta Neuropathol Commun. 2024 Jun 14;12(1):95. doi: 10.1186/s40478-024-01811-1.
10
Applied models and molecular characteristics of small cell lung cancer.小细胞肺癌的应用模型和分子特征。
Pathol Oncol Res. 2024 Apr 22;30:1611743. doi: 10.3389/pore.2024.1611743. eCollection 2024.
本文引用的文献
1
MYC activation is a hallmark of cancer initiation and maintenance.MYC激活是癌症起始和维持的一个标志。
Cold Spring Harb Perspect Med. 2014 Jun 2;4(6):a014241. doi: 10.1101/cshperspect.a014241.
2
MYC regulation of cell growth through control of transcription by RNA polymerases I and III.MYC 通过控制 RNA 聚合酶 I 和 III 的转录来调节细胞生长。
Cold Spring Harb Perspect Med. 2014 May 1;4(5):a018408. doi: 10.1101/cshperspect.a018408.
3
MYC and mitochondrial biogenesis.MYC与线粒体生物合成
Cold Spring Harb Perspect Med. 2014 May 1;4(5):a014225. doi: 10.1101/cshperspect.a014225.
4
c-MYC-induced genomic instability.c-MYC诱导的基因组不稳定。
Cold Spring Harb Perspect Med. 2014 Apr 1;4(4):a014373. doi: 10.1101/cshperspect.a014373.
5
The role of MIZ-1 in MYC-dependent tumorigenesis.MIZ-1 在 MYC 依赖性肿瘤发生中的作用。
Cold Spring Harb Perspect Med. 2013 Dec 1;3(12):a014290. doi: 10.1101/cshperspect.a014290.
6
Signatures of mutational processes in human cancer.人类癌症中的突变过程特征。
Nature. 2013 Aug 22;500(7463):415-21. doi: 10.1038/nature12477. Epub 2013 Aug 14.
7
MYC, metabolism, cell growth, and tumorigenesis.MYC、代谢、细胞生长和肿瘤发生。
Cold Spring Harb Perspect Med. 2013 Aug 1;3(8):a014217. doi: 10.1101/cshperspect.a014217.
8
RecQL4 helicase amplification is involved in human breast tumorigenesis.RecQL4 解旋酶扩增参与人类乳腺癌发生。
PLoS One. 2013 Jul 22;8(7):e69600. doi: 10.1371/journal.pone.0069600. Print 2013.
9
ATR phosphorylates SMARCAL1 to prevent replication fork collapse.ATR 使 SMARCAL1 磷酸化，以防止复制叉崩溃。
Genes Dev. 2013 Jul 15;27(14):1610-23. doi: 10.1101/gad.214080.113.
10
KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors.KDM4A 赖氨酸去甲基酶诱导肿瘤中扩增区域的特异性拷贝数增加和重复制。
Cell. 2013 Aug 1;154(3):541-55. doi: 10.1016/j.cell.2013.06.051. Epub 2013 Jul 18.
Zotero 插件