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罕见的鱼腥味综合征病例表现为抑郁。

A rare case of fish odor syndrome presenting as depression.

机构信息

Department of Psychiatry, Military Hospital, Danapur, Patna, Bihar, India.

M. A. Psychology, Research Scholar, Veer Kunwar Singh University, Patna, Bihar, India.

出版信息

Indian J Psychiatry. 2014 Apr;56(2):185-7. doi: 10.4103/0019-5545.130505.

DOI:10.4103/0019-5545.130505
PMID:24891709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4040069/
Abstract

A young lady presents to the psychiatry out-patient department with depressive symptoms. Evaluation revealed long standing stressor in the form of a foul odor emanating from her body and over a period of time resulting in social withdrawal and depression with significant impairment of day-to-day functioning. A diagnosis of trimethylaminurea (fish odor syndrome) and adjustment disorder was arrived at. Careful empathetic handling with psychoeducation, behavioral and cognitive counseling and a short course of antidepressants helped her improve significantly with return to almost normal functioning.

摘要

一位年轻女士因抑郁症状到精神科门诊就诊。评估发现,她长期以来一直受到身体散发恶臭的压力源的影响,随着时间的推移,导致她社交退缩和抑郁,严重影响了日常生活功能。最终诊断为三甲胺尿症(鱼腥综合征)和适应障碍。通过细心的同理心处理、心理教育、行为和认知咨询以及短期的抗抑郁药物治疗,她的病情显著改善,几乎恢复到正常功能。

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A rare case of fish odor syndrome presenting as depression.罕见的鱼腥味综合征病例表现为抑郁。
Indian J Psychiatry. 2014 Apr;56(2):185-7. doi: 10.4103/0019-5545.130505.
2
Trimethylaminuria (fish-odor syndrome): a case report.三甲胺尿症(鱼臭综合征):一例报告。
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引用本文的文献

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Engineered Polymersomes for the Treatment of Fish Odor Syndrome: A First Randomized Double Blind Olfactory Study.用于治疗鱼腥味综合征的工程化聚合物囊泡:首例随机双盲嗅觉研究。
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The genetic and biochemical basis of trimethylaminuria in an Irish cohort.爱尔兰人群中三甲胺尿症的遗传和生化基础。
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Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk.黄素单加氧酶 3 是机体三甲基胺 N-氧化物生成途径中的主要肝酶,可调节血小板反应性和血栓形成风险。
J Thromb Haemost. 2018 Sep;16(9):1857-1872. doi: 10.1111/jth.14234. Epub 2018 Aug 9.
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Fish Malodour syndrome in a child.一名儿童的鱼腥味综合征
BMJ Case Rep. 2015 Apr 13;2015:bcr2014207002. doi: 10.1136/bcr-2014-207002.

本文引用的文献

1
Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients.膳食补充剂活性炭和叶绿酸铜对日本三甲胺尿症患者尿中三甲胺排泄的影响。
Life Sci. 2004 Apr 16;74(22):2739-47. doi: 10.1016/j.lfs.2003.10.022.
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Trimethylaminuria: the fish malodor syndrome.三甲胺尿症:鱼腥味综合征。
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Mild trimethylaminuria caused by common variants in FMO3 gene.由FMO3基因常见变异引起的轻度三甲胺尿症。
Lancet. 1999 Sep 4;354(9181):834-5. doi: 10.1016/s0140-6736(99)80019-1.
4
Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication.含黄素单加氧酶基因(FMO3)的突变会导致三甲胺尿症,这是一种解毒缺陷疾病。
Hum Mol Genet. 1998 May;7(5):839-45. doi: 10.1093/hmg/7.5.839.
5
Trimethylaminuria, fish odour syndrome: a new method of detection and response to treatment with metronidazole.三甲胺尿症,鱼腥味综合征:一种新的检测方法及甲硝唑治疗反应
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Trimethylaminuria: the fish-odour syndrome.
Lancet. 1970 Oct 10;2(7676):770-1. doi: 10.1016/s0140-6736(70)90241-2.