腺苷酸活化蛋白激酶（AMPK）：作为细胞能量状态的主要调节因子，它能否区分胰岛素敏感型和胰岛素抵抗型肥胖？
AMP-activated Protein Kinase (AMPK): Does This Master Regulator of Cellular Energy State Distinguish Insulin Sensitive from Insulin Resistant Obesity?
机构信息
Diabetes and Metabolism Unit, Section of Endocrinology, Department of Medicine, Boston University Medical Center, 650 Albany Street, Room 820, Boston, MA 02118, USA.
出版信息
Curr Obes Rep. 2014 Jun 1;3(2):248-55. doi: 10.1007/s13679-014-0095-x.
Abstract
Although a correlation exists between obesity and insulin resistance, roughly 25 % of obese individuals are insulin sensitive. AMP-activated protein kinase (AMPK) is a cellular energy sensor that among its many actions, integrates diverse physiological signals to restore energy balance. In addition, in many situations it also increases insulin sensitivity. In this context, AMPK activity is decreased in very obese individuals undergoing bariatric surgery who are insulin resistant compared to equally obese patients who are insulin sensitive. In this review, we will both explore what distinguishes these individuals, and evaluate the evidence that diminished AMPK is associated with insulin resistance and metabolic syndrome-associated disorders in other circumstances.
摘要
虽然肥胖与胰岛素抵抗之间存在相关性，但大约 25%的肥胖个体对胰岛素敏感。AMP 激活的蛋白激酶 (AMPK) 是一种细胞能量传感器，它在许多作用中整合了各种生理信号以恢复能量平衡。此外，在许多情况下，它还能增加胰岛素敏感性。在这种情况下，与同样肥胖但对胰岛素敏感的患者相比，接受减肥手术的肥胖个体的 AMPK 活性降低，并且表现出胰岛素抵抗。在这篇综述中，我们将探讨是什么将这些个体区分开来，并评估在其他情况下，AMPK 活性降低与胰岛素抵抗和代谢综合征相关疾病之间的关系的证据。
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本文引用的文献
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Mol Metab. 2013 Oct 23;3(1):5-18. doi: 10.1016/j.molmet.2013.10.006. eCollection 2014 Feb.
2
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Diabetes. 2013 Oct;62(10):3341-9. doi: 10.2337/db13-0844.
3
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4
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J Biol Chem. 2013 Sep 27;288(39):28324-30. doi: 10.1074/jbc.C113.495473. Epub 2013 Aug 13.
5
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6
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