Centro de Estudios para la Medición de la Actividad Física CEMA, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, 111221, Colombia.
Laboratorio de Ciencias de la Actividad Física, el Deporte y la Salud, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, USACH, 7500618, Santiago, Chile.
Lipids Health Dis. 2019 Jan 22;18(1):23. doi: 10.1186/s12944-019-0962-2.
Elevated levels of fetuin-A are associated with increased risks of metabolic syndrome, type 2 diabetes and nonalcoholic fatty liver disease. This meta-analysis investigated whether exercise interventions can reduce fetuin-A in adults.
We searched clinical trials that objectively assessed fetuin-A and included study arms with exercise intervention. The pre-intervention and post-intervention data were used for meta-analysis. The effect sizes were calculated as standardized mean differences or changes in fetuin-A and expressed as Hedges' g using random-effects models.
The overall Hedges' g for fetuin-A in all included interventions was - 0.640 (95%CI - 1.129 to - 0.151; n = 9), but this effect was not observed in obese (g = - 0.096; 95%CI, - 0.328 to 0.135) and type 2 diabetes/dysglycemia (g = - 0.56; 95%CI, - 1.348 to 0.236) individuals. Additionally, the random-effects meta-regression analysis showed that there was not a greater decrease in fetuin-A in individuals who achieved greater body mass index reductions (regression coefficient = 0.065; 95%CI, - 0.185 to 0.315).
Supervised exercise is associated with reductions in fetuin-A levels in adults and elderly. However, the results of the present meta-analysis should be interpreted with caution because of the variety of type of exercises and individual obesity related-disorders involve. Therefore, additional high-quality randomized controlled trials describing the effect of supervised exercise interventions on fetuin-A in adults are still needed. .
胎球蛋白-A 水平升高与代谢综合征、2 型糖尿病和非酒精性脂肪性肝病的风险增加有关。本荟萃分析旨在探讨运动干预是否可以降低成年人的胎球蛋白-A 水平。
我们检索了客观评估胎球蛋白-A 并包含运动干预组的临床试验。使用荟萃分析了干预前和干预后的数据。使用随机效应模型计算效应大小作为标准化均数差或胎球蛋白-A 的变化，并表示为 Hedges'g。
所有纳入干预措施的胎球蛋白-A 的总体 Hedges'g 为-0.640（95%CI-1.129 至-0.151；n=9），但在肥胖者（g=-0.096；95%CI，-0.328 至 0.135）和 2 型糖尿病/糖调节受损者（g=-0.56；95%CI，-0.348 至 0.236）中未观察到这种效果。此外，随机效应荟萃回归分析表明，胎球蛋白-A 降低幅度在体重指数降低幅度较大的个体中并没有更大（回归系数=0.065；95%CI，-0.185 至 0.315）。
在成年人和老年人中，监督性运动与胎球蛋白-A 水平的降低有关。然而，由于涉及的运动类型和个体肥胖相关疾病的多样性，本荟萃分析的结果应谨慎解释。因此，仍需要更多高质量的随机对照试验来描述监督性运动干预对成年人胎球蛋白-A 的影响。
