脱氧胆酸升高与特发性复发性急性胰腺炎：一例随访48个月的病例报告
Elevated Deoxycholic Acid and Idiopathic Recurrent Acute Pancreatitis: A Case Report With 48 Months of Follow-up.
作者信息
Plotnikoff Gregory A
机构信息
Penny George Institute for Health and Healing, Abbott Northwestern Hospital, Minneapolis, Minnesota, United States.
出版信息
Glob Adv Health Med. 2014 May;3(3):70-2. doi: 10.7453/gahmj.2014.016.
Recurrent pancreatitis is a potentially life-threatening condition with a well-established differential diagnosis. In a significant number of cases, no explanation exists. This case report documents one patient with a clear pattern of recurrent acute pancreatitis and no identifiable cause despite great effort. After 7 years of recurrent symptoms, she was found to have marked elevation of fecal deoxycholic acid (DCA), a secondary bile acid used to precipitate pancreatitis in animal models. This report documents cessation of symptoms/hospitalizations with normalization of her fecal DCA levels. This secondary bile acid is easily measured in stool. Needed now is an observational study of fecal DCA levels in patients with recurrent acute pancreatitis.
复发性胰腺炎是一种潜在的危及生命的疾病，其鉴别诊断已明确。在相当多的病例中，病因不明。本病例报告记录了一名患者，尽管经过大量努力，仍表现出复发性急性胰腺炎的明确模式且病因不明。经过7年的复发症状后，发现她的粪便脱氧胆酸（DCA）显著升高，DCA是一种继发性胆汁酸，在动物模型中可诱发胰腺炎。本报告记录了随着粪便DCA水平恢复正常，症状/住院情况停止。这种继发性胆汁酸在粪便中易于检测。目前需要对复发性急性胰腺炎患者的粪便DCA水平进行观察性研究。
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