J Clin Invest. 2014 Jun;124(6):2294-8. doi: 10.1172/JCI76825. Epub 2014 Jun 2.
Kidney disease is one of the most prevalent chronic conditions and is a frequent complication of diabetes, cardiovascular disease, and obesity. Recent advances in biomedical research and novel technologies have created opportunities to study kidney disease in a variety of platforms, applied to human populations. The Reviews in this series discuss the kidney in hypertension, diabetes, and monogenic forms of kidney disease, as well as the cellular and molecular mediators of acute kidney injury and fibrosis, IgA nephropathy and idiopathic membranous nephropathy, and kidney transplantation. In this introduction, we briefly review new insights into focal segmental glomerulosclerosis and the role of podocytes in health and disease. Additionally, we discuss how new technologies, therapeutics, and the availability of patient data can help shape the study of kidney disease and ultimately inform policies concerning biomedical research and health care.
肾脏病是最常见的慢性疾病之一，也是糖尿病、心血管疾病和肥胖症的常见并发症。生物医学研究和新技术的最新进展为在各种平台上研究肾脏病提供了机会，这些平台适用于人类群体。本系列评论讨论了高血压、糖尿病和单基因形式的肾脏病中的肾脏，以及急性肾损伤和纤维化、IgA 肾病和特发性膜性肾病的细胞和分子介质，以及肾移植。在这篇介绍中，我们简要回顾了局灶节段性肾小球硬化的新见解以及足细胞在健康和疾病中的作用。此外，我们还讨论了新技术、疗法以及患者数据的可用性如何帮助塑造肾脏病的研究，并最终为生物医学研究和医疗保健政策提供信息。
