原发性醛固酮增多症和原发性高血压患者尿醛固酮与舒张功能的关联。
Association between urine aldosterone and diastolic function in patients with primary aldosteronism and essential hypertension.
作者信息
Chang Yi-Yao, Lee Hsiu-Hao, Hung Chi-Sheng, Wu Xue-Ming, Lee Jen-Kuang, Wang Shuo-Meng, Liao Min-Tsun, Chen Ying-Hsien, Wu Vin-Cent, Wu Kwan-Dun, Lin Yen-Hung
机构信息
Cardiology Division of Cardiovascular Medical Center, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Department of Internal Medicine, Taipei City Hospital, Zhongxing Branch, Taipei, Taiwan; Institution of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan.
出版信息
Clin Biochem. 2014 Sep;47(13-14):1329-32. doi: 10.1016/j.clinbiochem.2014.05.062. Epub 2014 Jun 2.
OBJECTIVE
To investigate the association between aldosterone and cardiac diastolic dysfunction.
DESIGN AND METHODS
We prospectively enrolled 20 patients with primary aldosteronism (PA) and 22 patients with essential hypertension (EH). Plasma aldosterone concentration, plasma renin activity, and 24-h urine aldosterone level were measured. Echocardiography, including tissue Doppler image recordings, was performed.
RESULTS
PA patients had a significantly higher left ventricular (LV) mass index and worse LV diastolic function than those in EH patients. Among various measures of aldosterone, log-transformed 24-h urine aldosterone level had the most consistent correlation with diastolic function.
CONCLUSIONS
Aldosterone is strongly associated with LV diastolic dysfunction. Twenty-four hour urine aldosterone is a good indicator to evaluate the impact of aldosterone on LV diastolic function.
目的
探讨醛固酮与心脏舒张功能障碍之间的关联。
设计与方法
我们前瞻性纳入了20例原发性醛固酮增多症（PA）患者和22例原发性高血压（EH）患者。测量血浆醛固酮浓度、血浆肾素活性和24小时尿醛固酮水平。进行了超声心动图检查，包括组织多普勒图像记录。
结果
PA患者的左心室（LV）质量指数显著高于EH患者，且LV舒张功能更差。在醛固酮的各种测量指标中，经对数转换的24小时尿醛固酮水平与舒张功能的相关性最为一致。
结论
醛固酮与LV舒张功能障碍密切相关。24小时尿醛固酮是评估醛固酮对LV舒张功能影响的良好指标。
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