Dorsett Dale, Kassis Judith A
Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA.
Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Curr Biol. 2014 Jun 2;24(11):R535-9. doi: 10.1016/j.cub.2014.04.037.
The cohesin protein complex was discovered for its roles in sister chromatid cohesion and segregation, and the Polycomb group (PcG) proteins for their roles in epigenetic gene silencing during development. Cohesin also controls gene transcription via multiple mechanisms. Genetic and molecular evidence from Drosophila argue that cohesin and the PRC1 PcG complex interact to control transcription of many active genes that are critical for development, and that via these interactions cohesin also controls the availability of PRC1 for gene silencing.
黏连蛋白复合体因其在姐妹染色单体黏连和分离中的作用而被发现，而多梳蛋白家族（PcG）蛋白则因其在发育过程中表观遗传基因沉默中的作用而被发现。黏连蛋白还通过多种机制控制基因转录。来自果蝇的遗传和分子证据表明，黏连蛋白与PRC1 PcG复合体相互作用，以控制许多对发育至关重要的活性基因的转录，并且通过这些相互作用，黏连蛋白还控制PRC1用于基因沉默的可用性。
