Przkora Rene, Fram Ricki Y, Herndon David N, Suman Oscar E, Mlcak Ronald P
Department of Surgery, University of Texas Medical Branch, Galveston, TX, United States; Shriners Hospitals for Children, Galveston, TX, United States; Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, United States.
Department of Surgery, University of Texas Medical Branch, Galveston, TX, United States; Shriners Hospitals for Children, Galveston, TX, United States.
Burns. 2014 Dec;40(8):1487-91. doi: 10.1016/j.burns.2014.04.019. Epub 2014 Jun 2.
Determine the effect of inhalation injury on burn-induced hypermetabolism in children.
Prospective study comparing hypermetabolism (i.e., resting energy expenditure and oxygen consumption) in burned children with and without inhalation injury during acute hospitalization.
Single pediatric burn center.
Eighty-six children (1-18 years) with ≥40% total body surface area burns were stratified to two groups: no inhalation injury and inhalation injury.
None.
Inhalation injury was diagnosed based on bronchoscopic evaluation. At admission, PaO2:FiO2 ratios (an index of respiratory distress) were significantly higher in patients with no inhalation injury than in patients with inhalation injury. No differences were detected in resting energy expenditure or percent of the predicted basal metabolic rate between groups. Additionally, oxygen consumption did not significantly differ between groups.
Inhalation injury does not augment the burn-induced hypermetabolic stress response in children, as reflected by resting energy expenditure and oxygen consumption.
确定吸入性损伤对儿童烧伤后高代谢的影响。
前瞻性研究，比较急性住院期间有或无吸入性损伤的烧伤儿童的高代谢情况（即静息能量消耗和氧耗）。
单一儿科烧伤中心。
86名全身表面积烧伤≥40%的儿童（1 - 18岁）被分为两组：无吸入性损伤组和吸入性损伤组。
无。
根据支气管镜评估诊断吸入性损伤。入院时，无吸入性损伤患者的动脉血氧分压与吸入氧分数值之比（呼吸窘迫指标）显著高于有吸入性损伤的患者。两组间静息能量消耗或预测基础代谢率百分比无差异。此外，两组间氧耗无显著差异。
如静息能量消耗和氧耗所示，吸入性损伤不会增强儿童烧伤后的高代谢应激反应。
