Neijts Melanie, Van Lien Rene, Kupper Nina, Boomsma Dorret, Willemsen Gonneke, de Geus Eco J C
Department of Biological Psychology, Vrije University (VU) Amsterdam, Amsterdam, The Netherlands; EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.
Psychophysiology. 2014 Oct;51(10):1023-36. doi: 10.1111/psyp.12246. Epub 2014 Jun 3.
This study estimated the heritability of 24-h heart rate variability (HRV) measures, while considering ceiling effects on HRV at low heart rates during the night. HRV was indexed by the standard deviation of all valid interbeat intervals (SDNN), the root mean square of differences between valid, successive interbeat intervals (RMSSD), and peak-valley respiratory sinus arrhythmia (pvRSA). Sleep and waking levels of cardiac vagal control were assessed in 1,003 twins and 285 of their non-twin siblings. Comparable heritability estimates were found for SDNN (46%-53%), RMSSD (49%-54%), and pvRSA (48%-57%) during the day and night. A nighttime ceiling effect was revealed in 10.7% of participants by a quadratic relationship between mean pvRSA and the interbeat interval. Excluding these participants did not change the heritability estimates. The genetic factors influencing ambulatory pvRSA, RMSSD, and SDNN largely overlap. These results suggest that gene-finding studies may pool the different cardiac vagal indices and that exclusion of participants with low heart rates is not required.
本研究估计了24小时心率变异性（HRV）指标的遗传力，同时考虑了夜间低心率时HRV的天花板效应。HRV通过所有有效心搏间期的标准差（SDNN）、有效连续心搏间期之间差异的均方根（RMSSD）以及峰谷呼吸性窦性心律失常（pvRSA）来衡量。对1003对双胞胎及其285名非双胞胎兄弟姐妹的心脏迷走神经控制的睡眠和清醒水平进行了评估。白天和夜间，SDNN（46%-53%）、RMSSD（49%-54%）和pvRSA（48%-57%）的遗传力估计值相当。通过平均pvRSA与心搏间期之间的二次关系，在10.7%的参与者中发现了夜间天花板效应。排除这些参与者并没有改变遗传力估计值。影响动态pvRSA、RMSSD和SDNN的遗传因素在很大程度上重叠。这些结果表明，基因发现研究可以合并不同的心脏迷走神经指标，并且不需要排除心率较低的参与者。
