Vorozhtsov Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, pr. akademika Lavrent'eva 9, Novosibirsk 630090, Russian Federation; Novosibirsk State University, Pirogova str. 2, Novosibirsk 630090, Russian Federation.
Vorozhtsov Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, pr. akademika Lavrent'eva 9, Novosibirsk 630090, Russian Federation.
Bioorg Med Chem. 2014 Jul 15;22(14):3551-64. doi: 10.1016/j.bmc.2014.05.008. Epub 2014 May 13.
This review is the first attempt at systematization of the literature data on the structures and activities of triglyceride-lowering agents which used in medical practice or are in development. The effects and mechanisms of action of statins, squalene synthase inhibitors, fibrates, PPARα and PPARα/γ agonists, nicotinic acid, omega-3 fatty acids and some other molecular targets were considered. Unfortunately, to date, harmless and effective triglyceride-lowering drug still does not exist and there is still need for development of better triglyceride-lowering agents.
这篇综述首次对临床上使用或正在开发的具有降甘油三酯作用的药物的结构和活性的文献数据进行了系统的整理。文中讨论了他汀类药物、角鲨烯合酶抑制剂、贝特类药物、过氧化物酶体增殖物激活受体α和γ激动剂、烟酸、ω-3 脂肪酸和其他一些分子靶点的作用和作用机制。不幸的是，迄今为止，还没有一种安全有效的降甘油三酯药物，仍然需要开发更好的降甘油三酯药物。
