Front Biosci (Landmark Ed). 2014 Jun 1;19(8):1370-6. doi: 10.2741/4287.
The development of sepsis invovles the dysfunction of immunity due to an imbalance between the hyperimmune response and the immunoparalysis. Immune cells in both the innate and acquired immune system, including neutrophils, macrophages, dendritic cells, T cells and NK cells, are actively involved in the process. The interaction between immune cells, proinflammatory and anti-inflammatory cytokines contribute to the immunoparalysis in sepsis. Abnormal CD4+ and CD8+ T cell responses are major components of the deregulated acquired immune response in sepsis. Immune dysfunction of regulatory T cells (Tregs) contributes to the pathogensis of sepsis. Furthermore, IL-7 is essential for the replenishment and survival of T cells, which represents a promising target for immunotherapy of sepsis. In this review, we discusse the the immunoparalysis in the sepsis, with a focus on the deregulation of T cell response.
脓毒症的发生发展涉及免疫功能障碍，主要与过度的免疫反应和免疫麻痹失衡有关。固有免疫和适应性免疫系统中的免疫细胞，包括中性粒细胞、巨噬细胞、树突状细胞、T 细胞和自然杀伤（NK）细胞等，均积极参与这一过程。免疫细胞之间的相互作用、促炎和抗炎细胞因子的产生，共同导致脓毒症中的免疫麻痹。异常的 CD4+和 CD8+T 细胞反应是脓毒症中获得性免疫反应失调的主要组成部分。调节性 T 细胞（Treg）的免疫功能障碍导致脓毒症的发病机制。此外，白细胞介素-7（IL-7）对于 T 细胞的补充和存活至关重要，这使其成为脓毒症免疫治疗的一个有前途的靶点。在本综述中，我们讨论了脓毒症中的免疫麻痹，重点关注 T 细胞反应的失调。
