在脂肪生成和脂肪组织代谢中的 ID 转录调节因子。
Id transcriptional regulators in adipogenesis and adipose tissue metabolism.
出版信息
Front Biosci (Landmark Ed). 2014 Jun 1;19(8):1386-97. doi: 10.2741/4289.
Abstract
Id proteins (Id1-Id4) are helix-loop-helix (HLH) transcriptional regulators that lack a basic DNA binding domain. They act as negative regulators of basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibit their DNA binding and transcriptional activity. Id proteins are implicated in the regulation of various cellular mechanisms such as cell proliferation, cellular differentiation, cell fate determination, angiogenesis and tumorigenesis. A handful of recent studies also disclosed that Id proteins have critical functions in adipocyte differentiation and adipose tissue metabolism. Here, we reviewed the progress made thus far in understanding the specific functions of Id proteins in adipose tissue differentiation and metabolism. In addition to reviewing the known mechanisms of action, we also discuss possible additional mechanisms in which Id proteins might participate in regulating adipogenic and metabolic pathways.
摘要
Id 蛋白（Id1-Id4）是螺旋-环-螺旋（HLH）转录调节因子，缺乏碱性 DNA 结合域。它们通过形成异二聚体作为碱性螺旋-环-螺旋（bHLH）转录因子的负调节剂，抑制其 DNA 结合和转录活性。Id 蛋白参与调节多种细胞机制，如细胞增殖、细胞分化、细胞命运决定、血管生成和肿瘤发生。最近的一些研究也揭示了 Id 蛋白在脂肪细胞分化和脂肪组织代谢中具有关键功能。在这里，我们综述了迄今为止在理解 Id 蛋白在脂肪组织分化和代谢中的特定功能方面所取得的进展。除了回顾已知的作用机制外，我们还讨论了 Id 蛋白可能参与调节脂肪生成和代谢途径的其他可能机制。
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