Jung Ju-Yang, Koh Bo-Ram, Kim Hyoun-Ah, Jeon Ja-Young, Suh Chang-Hee
From the Department of Rheumatology, Ajou University School of Medicine, Suwon, Korea.
J Investig Med. 2014 Aug;62(6):890-3. doi: 10.1097/JIM.0000000000000094.
Anti-C-reactive protein (CRP) antibodies have been described in patients with systemic lupus erythematosus (SLE). We investigated the potential of the anti-CRP antibody as a marker for disease activity in SLE patients and as a predictor of progression to SLE in patients with incomplete lupus.
Immunoglobulin G anti-CRP antibody levels were measured using an enzyme-linked immunosorbent assay.
Patients with incomplete lupus exhibited clinical and immunologic characteristics different from those in SLE patients: no serositis and alopecia, more common oral ulcers and arthritis, lower disease activity index, lower positivity for antinuclear and anti-double-strand DNA antibodies, and higher complement levels. Anti-CRP antibody levels were higher in SLE patients (35.6 [35.1] AU) than in patients with incomplete lupus (23.1 [25.8] AU, P = 0.016) and normal controls (21.0 [14.3] AU, P < 0.001). Anti-CRP antibody was significantly higher in SLE patients with arthritis and correlated with disease activity markers, including antichromatin antibody. However, no difference in anti-CRP antibody levels was observed between patients with incomplete lupus that progressed to SLE and those whose did not.
These data suggest that anti-CRP antibodies can neither be used as biomarkers in SLE nor predict SLE progression in patients with incomplete lupus.
系统性红斑狼疮（SLE）患者体内已发现抗C反应蛋白（CRP）抗体。我们研究了抗CRP抗体作为SLE患者疾病活动标志物以及不完全性狼疮患者进展为SLE的预测指标的潜力。
采用酶联免疫吸附测定法检测免疫球蛋白G抗CRP抗体水平。
不完全性狼疮患者表现出与SLE患者不同的临床和免疫学特征：无浆膜炎和脱发，口腔溃疡和关节炎更常见，疾病活动指数较低，抗核抗体和抗双链DNA抗体阳性率较低，补体水平较高。SLE患者的抗CRP抗体水平（35.6 [35.1] AU）高于不完全性狼疮患者（23.1 [25.8] AU，P = 0.016）和正常对照（21.0 [14.3] AU，P < 0.001）。患有关节炎的SLE患者抗CRP抗体明显更高，且与包括抗染色质抗体在内的疾病活动标志物相关。然而，进展为SLE的不完全性狼疮患者与未进展者之间的抗CRP抗体水平未观察到差异。
这些数据表明抗CRP抗体既不能用作SLE的生物标志物，也不能预测不完全性狼疮患者的SLE进展。
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