Patelarou Evridiki, Kelly Frank J
Florence Nightingale School of Nursing and Midwifery, King's College London, London SE18WA, UK.
NIHR Environmental Hazards Health Protection Research Unit, MRC-PHE Centre for Environment and Health, King's College London, London SE19NH, UK.
Int J Environ Res Public Health. 2014 Jun 3;11(6):5904-33. doi: 10.3390/ijerph110605904.
The purpose of this review was to summarize existing epidemiological evidence of the association between quantitative estimates of indoor air pollution and all-day personal exposure with adverse birth outcomes including fetal growth, prematurity and miscarriage. We carried out a systematic literature search of MEDLINE and EMBASE databases with the aim of summarizing and evaluating the results of peer-reviewed epidemiological studies undertaken in "westernized" countries that have assessed indoor air pollution and all-day personal exposure with specific quantitative methods. This comprehensive literature search identified 16 independent studies which were deemed relevant for further review and two additional studies were added through searching the reference lists of all included studies. Two reviewers independently and critically appraised all eligible articles using the Critical Appraisal Skills Programme (CASP) tool. Of the 18 selected studies, 14 adopted a prospective cohort design, three were case-controls and one was a retrospective cohort study. In terms of pollutants of interest, seven studies assessed exposure to electro-magnetic fields, four studies assessed exposure to polycyclic aromatic hydrocarbons, four studies assessed PM2.5 exposure and three studies assessed benzene, phthalates and noise exposure respectively. Furthermore, 12 studies examined infant growth as the main birth outcome of interest, six examined spontaneous abortion and three studies assessed gestational age at birth and preterm delivery. This survey demonstrates that there is insufficient research on the possible association of indoor exposure and early life effects and that further research is needed.
本综述的目的是总结室内空气污染定量评估及全天个人暴露与不良出生结局（包括胎儿生长、早产和流产）之间关联的现有流行病学证据。我们对MEDLINE和EMBASE数据库进行了系统的文献检索，目的是总结和评估在“西方化”国家开展的、采用特定定量方法评估室内空气污染和全天个人暴露的同行评审流行病学研究结果。这项全面的文献检索确定了16项被认为与进一步综述相关的独立研究，并通过搜索所有纳入研究的参考文献列表又增加了两项研究。两名评审员使用批判性评估技能计划（CASP）工具独立且严格地评估了所有符合条件的文章。在所选的18项研究中，14项采用了前瞻性队列设计，3项为病例对照研究，1项为回顾性队列研究。在感兴趣的污染物方面，7项研究评估了电磁场暴露，4项研究评估了多环芳烃暴露，4项研究评估了PM2.5暴露，3项研究分别评估了苯、邻苯二甲酸盐和噪声暴露。此外，12项研究将婴儿生长作为主要关注的出生结局进行了研究，6项研究考察了自然流产，3项研究评估了出生时的孕周和早产情况。这项调查表明，关于室内暴露与早期生活影响之间可能存在的关联，研究尚不充分，需要进一步开展研究。
