Rosenstein Adam K, Machler Brian C, Rosenstein Elliot D
Institute for Rheumatic and Autoimmune Diseases, Overlook Medical Center, 33 Overlook Rd, Summit, NJ, USA.
Cutis. 2014 May;93(5):E13-6.
Alopecia areata (AA) is a complication of biologic therapy with several anti-tumor necrosis factor (TNF) inhibitors and efalizumab for the treatment of various autoimmune diseases. We report the case of a 51-year-old woman who developed AA universalis while undergoing treatment with daclizumab, an immunosuppressive biologic therapy, administered for treatment of inflammatory ocular disease. Although immunomodulatory agents that function by interfering with T helper cell stimulation are expected to impede autoimmune-related processes, we believe that daclizumab may be causally related to the development of AA.
