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华法林药物基因组学试验：药物基因组学指导剂量是否有未来？

Warfarin pharmacogenetic trials: is there a future for pharmacogenetic-guided dosing?

机构信息

Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1497, New York, NY 10029, USA.

出版信息

Pharmacogenomics. 2014 Apr;15(6):719-22. doi: 10.2217/pgs.14.18.

DOI:10.2217/pgs.14.18
PMID:24897277
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4110075/
Abstract

“In clinical practice, it is common for warfarin to be initiated at a fixed dose for the first several doses.”

摘要

在临床实践中，华法林通常在前几次剂量中采用固定剂量起始。

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A randomized trial of genotype-guided dosing of warfarin.华法林基因指导剂量的随机试验。
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A pharmacogenetic versus a clinical algorithm for warfarin dosing.基于药理学的华法林剂量调整算法与临床算法的比较。
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A randomized and clinical effectiveness trial comparing two pharmacogenetic algorithms and standard care for individualizing warfarin dosing (CoumaGen-II).比较两种基于遗传药理学算法和标准护理的华法林个体化剂量方案的随机、临床有效性试验（CoumaGen-II）。
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Executive summary: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.执行摘要：《抗栓治疗与血栓形成预防》第9版：美国胸科医师学会循证临床实践指南。
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Prospective evaluation of a pharmacogenetics-guided warfarin loading and maintenance dose regimen for initiation of therapy.前瞻性评估基于药物遗传学的华法林起始治疗负荷剂量和维持剂量方案。
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Genetics informatics trial (GIFT) of warfarin to prevent deep vein thrombosis (DVT): rationale and study design.华法林预防深静脉血栓形成（DVT）的遗传学信息学试验（GIFT）：基本原理和研究设计。
Pharmacogenomics J. 2012 Oct;12(5):417-24. doi: 10.1038/tpj.2011.18. Epub 2011 May 24.
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Genet Med. 2011 Jun;13(6):505-8. doi: 10.1097/GIM.0b013e31821db51a.
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Warfarin genotyping reduces hospitalization rates results from the MM-WES (Medco-Mayo Warfarin Effectiveness study).华法林基因分型降低了住院率，这是 MM-WES（美科梅奥华法林有效性研究）的结果。
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