纳洛酮不影响雄性瑞士小鼠因管约束引起的目标咬噬行为。

Naloxone does not affect tube restraint-induced target biting by male Swiss mice.

作者信息

McAllister K H, Berry M S

机构信息

Department of Zoology, University College of Swansea, Singleton Park, Swansea, SA2 8PP, Wales, U.K.

出版信息

Behav Processes. 1985 May;10(4):429-36. doi: 10.1016/0376-6357(85)90042-7.

DOI:10.1016/0376-6357(85)90042-7

PMID:24897577

Abstract

Opioid peptides have been implicated in the mediation of intermale conflict. The effect of naloxone upon tube restraint-induced target biting was investigated since a high correlation between bite scores and intermale aggression has been claimed. No significant modification of target biting behaviour by naloxone was produced, in mice either naive or habituated to the apparatus (high and low baselines of responding respectively) suggesting no involvement of opioid peptides in this paradigm. The results are discussed in terms of controllability of the presumably stressful situation and the relation of restraint-induced biting to conspecific aggression.

摘要

阿片肽被认为参与了雄性间冲突的调节。由于有人声称咬痕评分与雄性间攻击行为之间存在高度相关性，因此研究了纳洛酮对管束缚诱导的目标咬咬行为的影响。无论是未接触过该装置的小鼠还是已适应该装置的小鼠（分别为高和低反应基线），纳洛酮均未对目标咬咬行为产生显著改变，这表明阿片肽在该范式中未发挥作用。根据推测的应激情况的可控性以及束缚诱导的咬咬行为与同种攻击行为的关系对结果进行了讨论。