铜介导的由2,3-联烯酸酯或2-炔酸酯、胺和腈合成吡唑。
Copper-mediated pyrazole synthesis from 2,3-allenoates or 2-alkynoates, amines and nitriles.
作者信息
Chen Bo, Zhu Can, Tang Yang, Ma Shengming
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, P. R. China.
出版信息
Chem Commun (Camb). 2014 Jul 21;50(57):7677-9. doi: 10.1039/c4cc02856b.
PMID:24897944
Abstract
An efficient copper-mediated three-component reaction of 2,3-allenoates or 2-alkynoates, amines, and nitriles affording fully substituted pyrazoles with a very nice diversity has been developed. A tandem conjugate addition, 1,2-addition, and N-N bond formation mechanism has been proposed for this diverse synthesis of pyrazoles based on mechanistic studies.
摘要
已开发出一种高效的铜介导的2,3-联烯酸酯或2-炔酸酯、胺和腈的三组分反应，可提供具有非常好的多样性的全取代吡唑。基于机理研究，已为这种多样化的吡唑合成提出了串联共轭加成、1,2-加成和N-N键形成机理。
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