Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland; Institute of Dentistry, University of Misurata, Misurata, Libya.
Histopathology. 2014 Nov;65(5):587-94. doi: 10.1111/his.12471. Epub 2014 Oct 6.
Tumour budding is a specific type of invasive growth in carcinomas characterized by invading single tumour cells or small clusters of tumour cells (<5 cells) at the invasive front (IF). It has been documented in numerous publications during the past few decades, but its value as a prognostic marker in head and neck squamous cell carcinoma (HNSCC) has been analysed only recently. In this review we aimed to address the question of whether or not tumour budding has an impact upon the progression and prognosis of HNSCC. We systematically reviewed the databases of PubMed, Scopus and Web of Science for articles that studied tumour budding in squamous cell carcinoma of the head and neck region. The search was limited to articles published in the English literature before March 2014. A total of 122 hits were retrieved; however, only five reports met the inclusion criteria. The findings of these reports suggested a strong association between tumour budding and tumour progression, in addition to strong correlation with patient prognosis. Standardization of the scoring method and the risk stratification cut-off point is necessary before the inclusion of tumour budding in pathological reports during daily practice.
肿瘤芽殖是一种特定类型的浸润性生长，在癌中表现为侵袭性前缘（IF）单个肿瘤细胞或小簇肿瘤细胞（<5 个细胞）的浸润。在过去几十年的大量出版物中已经有记载，但最近才分析了其作为头颈部鳞状细胞癌（HNSCC）预后标志物的价值。在这篇综述中，我们旨在探讨肿瘤芽殖是否对头颈部鳞状细胞癌的进展和预后有影响。我们系统地检索了 PubMed、Scopus 和 Web of Science 数据库中研究头颈部鳞状细胞癌肿瘤芽殖的文章。检索仅限于 2014 年 3 月之前发表的英文文献。共检索到 122 个结果，但只有 5 篇报告符合纳入标准。这些报告的结果表明，肿瘤芽殖与肿瘤进展之间存在很强的关联，并且与患者预后有很强的相关性。在日常实践中，将肿瘤芽殖纳入病理报告之前，需要对评分方法和风险分层截断点进行标准化。
