Fasunla Ayotunde James, Douglas David Dayo, Adeosun Aderemi Adeleke, Steinbach Silke, Nwaorgu Onyekwere George Benjamin
Department of Otorhinolaryngology, College of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria
Department of Otorhinolaryngology, University College Hospital, Ibadan, Nigeria.
Otolaryngol Head Neck Surg. 2014 Sep;151(3):438-42. doi: 10.1177/0194599814536851. Epub 2014 Jun 4.
To assess the olfactory threshold of healthy volunteers at the University College Hospital, Ibadan and to investigate the effect of perfume on their olfactory detection thresholds.
A quasi-experimental study on olfactory detection thresholds of healthy volunteers from September 2013 to November 2013.
Tertiary health institution.
A structured questionniare was administered to the participants in order to obtain information on sociodemographics, occupation, ability to perceive smell, use of perfume, effects of perfume on appetite and self-confidence, history of allergy, and previous nasal surgery. Participants subjectively rated their olfactory performance. Subsequently, they had olfactory detection threshold testing done at baseline and after exposure to perfume with varied concentrations of n-butanol in a forced triple response and staircase fashion.
Healthy volunteers, 37 males and 63 females, were evaluated. Their ages ranged from 19 to 59 years with a mean of 31 years ± 8. Subjectively, 94% of the participants had excellent olfactory function. In the pre-exposure forced triple response, 88% were able to detect the odor at ≤.25 mmol/l concentration while in the post-exposure forced triple response, only 66% were able to detect the odor at ≤.25 mmol/l concentration. There is also a statistical significant difference in the olfactory detection threshold score between the pre-exposure and post-exposure period in the participants (P < .05).
Use of strong fragrances affects the olfactory detection threshold. Therefore patients and clinicians should be aware of this and its effects on the outcome of test of olfaction.
评估伊巴丹大学学院医院健康志愿者的嗅觉阈值，并研究香水对其嗅觉检测阈值的影响。
2013年9月至2013年11月对健康志愿者嗅觉检测阈值进行的一项准实验研究。
三级医疗机构。
向参与者发放一份结构化问卷，以获取有关社会人口统计学、职业、嗅觉感知能力、香水使用情况、香水对食欲和自信心的影响、过敏史以及既往鼻部手术史等信息。参与者对自己的嗅觉表现进行主观评分。随后，他们在基线时以及暴露于不同浓度正丁醇的香水后，以强制三联反应和阶梯法进行嗅觉检测阈值测试。
对37名男性和63名女性健康志愿者进行了评估。他们的年龄在19岁至59岁之间，平均年龄为31岁±8岁。主观上，94%的参与者嗅觉功能极佳。在暴露前的强制三联反应中，88%的人能够在浓度≤0.25 mmol/l时检测到气味，而在暴露后的强制三联反应中，只有66%的人能够在浓度≤0.25 mmol/l时检测到气味。参与者在暴露前和暴露后的嗅觉检测阈值评分也存在统计学显著差异（P < 0.05）。
使用浓烈香水会影响嗅觉检测阈值。因此，患者和临床医生应意识到这一点及其对嗅觉测试结果的影响。
