Department of Medicine and Department of Genetics, Cardiovascular Institute, and Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sci Transl Med. 2014 Jun 4;6(239):239ps4. doi: 10.1126/scitranslmed.3008535.
The development of new therapies for coronary artery disease (CAD) poses a substantial challenge, and several recent approaches have failed for lack of efficacy. Human genetics has the potential to identify new targets for which the likelihood of therapeutic success is considerably greater. The intense focus on the genetics of CAD will revitalize the field and lead to future therapies for this common disease.
冠状动脉疾病（CAD）新疗法的研发面临着巨大的挑战，而最近的几种方法由于缺乏疗效而失败。人类遗传学有可能为那些具有更高治疗成功率的新靶点提供依据。对 CAD 遗传学的高度关注将使该领域恢复活力，并为这种常见疾病带来未来的治疗方法。
