Adhyapak Srilakshmi M, Menon Prahlad G, Parachuri V Rao, Gadabanahalli Karthik, Bhat Venkat Ramana, Shetty Varun, Shetty Devi
Department of Cardiology, St John's Medical College Hospital, Bangalore, India
Department of Electrical and Computer Engineering, SYSU-CMU Joint Institute of Engineering, Pittsburgh, USA Shunde International Research Institute, Guangdong, China QuantMD LLC, Pittsburgh, USA.
Interact Cardiovasc Thorac Surg. 2014 Sep;19(3):398-405. doi: 10.1093/icvts/ivu173. Epub 2014 Jun 4.
Clinical outcomes of surgical ventricular restoration (SVR) have been confirmed by Registry data. Accurate assessment of left ventricular (LV) morphology and function can help optimize these outcomes.
LV remodelling in 7 patients (NYHA class 3 ± 1.2) with post-myocardial infarction LV aneurysms was characterized by the regional LV volume (RLVV) computed by dividing the LV in cine steady-state free precession cardiac magnetic resonance imaging (CMR) at each slice level into six radial segments. Rotation of the LV apex and base was analysed using tagged CMR. The apical conicity ratio was used to characterize the restored apical geometry.
The mean end-diastolic volume (EDV) was 174.8 ± 100.3 ml and the mean ejection fraction (EF) was 18.8 ± 7.8%. Following SVR, all patients had significant clinical improvements (NYHA Class I), and significant increases in the left ventricular ejection fraction (LVEF) to 38.8 ± 4.4%. The LV volumes and regional volumes at the base and apex decreased with a trend towards significance. The mean preoperative apical conicity ratio (ACR) was 1.90 ± 0.43 and, following SVR by endoventricular linear patch plasty (EVLPP), was 1.35 ± 0.3 (P = 0.02). The percent decrease in the ACR following SVR from baseline was 28.68 ± 10.98%. The apical EF increased from 1.19 ± 13.9 to 15.8 ± 8.2% (P = 0.028). The basal rotations improved from 3.13 ± 2.1 to 4.69 ± 2.94° (P = 0.04). The apical rotations also improved significantly from 2.48 ± 1.23 to 3.93 ± 2.45° (P = 0.05) and reversed to the normal anticlockwise direction.
SVR by geometric repair using a rectangular intracavitary patch helps restoration of a physiological apex with normalization of apical rotation reflecting a near-physiological LV function.
登记数据已证实了手术性心室修复(SVR)的临床疗效。准确评估左心室(LV)形态和功能有助于优化这些疗效。
对7例患有心肌梗死后左心室室壁瘤的患者(纽约心脏协会心功能分级为3±1.2级),通过在电影稳态自由进动心脏磁共振成像(CMR)中,将每个层面的左心室划分为六个径向节段来计算局部左心室容积(RLVV),以此来表征左心室重构情况。使用标记CMR分析左心室心尖和心底的旋转情况。心尖圆锥度比用于表征修复后的心尖几何形状。
平均舒张末期容积(EDV)为174.8±100.3ml,平均射血分数(EF)为18.8±7.8%。SVR术后,所有患者临床症状均有显著改善(纽约心脏协会心功能分级为I级),左心室射血分数(LVEF)显著提高至38.8±4.4%。心底和心尖处的左心室容积及局部容积减小,且有显著趋势。术前平均心尖圆锥度比(ACR)为1.90±0.43,采用心室内线性补片成形术(EVLPP)进行SVR术后,ACR为1.35±0.3(P = 0.02)。SVR术后ACR较基线水平下降的百分比为28.68±10.98%。心尖处EF从1.19±13.9提高至15.8±8.2%(P = 0.028)。心底旋转角度从3.13±2.1改善至4.69±2.94°(P = 0.04)。心尖旋转角度也从2.48±1.23显著改善至3.93±2.45°(P = 0.05),并逆转至正常逆时针方向。
使用矩形心腔内补片进行几何修复的SVR有助于恢复生理性心尖,使心尖旋转正常化,反映出近乎生理性的左心室功能。