Jalilian Amir R, Anvari Akbar, Bahrami-Samani Ali, Mazidi Mohammad, Ghannadi-Maragheh Mohammad
Radiopharmaceutical Research and Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran 14155-1339.
Faculty of Nuclear Engineering, Shahid Beheshti University, P.O. Box: 19839-63113, Tehran, Iran.
Nucl Med Mol Imaging. 2011 Jun;45(2):87-92. doi: 10.1007/s13139-010-0048-6. Epub 2011 Feb 17.
(66)Ho-chloride was obtained by bombardment of natural Ho(NO3)3 dissolved in acidic media using thermal neutron flux (4-5 × 10(13) n.cm(-2).s(-1)).
(166)Ho-holmium chloride (185 MBq) was used successfully for preparation of (166)Ho-phytate complex with high radiochemical purity (>99.9 %, ITLC, MeOH: H2O: acetic acid, 4: 4: 2, as mobile phase). The complex stability and viscosity were checked in the final solution up to 2 days. The prepared complex solution (60 μCi/100 μl) was injected intraarticularly to male rat knee joints. Leakage of radioactivity from the injection site and its distribution in organs were investigated up to 2 days.
Approximately all of the injected dose had remained in the injection site 2 days after injection.
The complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology.
通过使用热中子通量(4 - 5×10¹³ n·cm⁻²·s⁻¹)轰击溶解在酸性介质中的天然硝酸钬(Ho(NO₃)₃)获得氯化钬(Ho - 氯化物)。
成功使用氯化钬(¹⁶⁶Ho - 185 MBq)制备了放射化学纯度高(>99.9%,以甲醇:水:乙酸,4:4:2作为流动相的ITLC法)的¹⁶⁶Ho - 植酸盐复合物。在最终溶液中检查复合物稳定性和粘度长达2天。将制备的复合物溶液(60 μCi/100 μl)关节腔内注射到雄性大鼠膝关节。研究注射部位放射性泄漏及其在器官中的分布长达2天。
注射2天后,几乎所有注射剂量仍留在留在注射部位。
该复合物被证明是肿瘤学和风湿病学中空腔放射治疗的可行药物。