用于放射性滑膜切除术的镥-177植酸盐复合物的制备与评价

Preparation and evaluation of Lu-(177) phytate Complex for Radiosynovectomy.

作者信息

Yousefnia Hassan, Jalilian Amir Reza, Zolghadri Samaneh

机构信息

Radiopharmacy Research Group, Radiation Application Research School, Nuclear Science and Technology Research Institute, P.O.Box:14395-836, Tehran, Iran.

出版信息

World J Nucl Med. 2014 Jan;13(1):22-7. doi: 10.4103/1450-1147.138570.

DOI:10.4103/1450-1147.138570

PMID:25191108

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4149764/

Abstract

Lu-(177) of 2.6-3 GBq/mg specific activity was obtained by irradiation of natural Lu2O3 sample with thermal neutron flux of 4 × 10(13) n/cm/s. The product was converted into chloride form which was further used for labeling of Lu(-177) phytate complex successfully with high radiochemical purity (>99.9%, instant thin layer chromatography, MeOH: H2O: Acetic acid, 4:4:2, as mobile phase). The complex stability and viscosity were checked in the final solution up to 7 days. The prepared complex solution (100 μCi/100 μl) was injected intra-articularly to the male rat knee joint. Leakage of radioactivity from the injection site and its distribution in organs were investigated up to 7 days. Approximately, all injected dose has remained in injection site 7 days after injection. The complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology.

摘要

通过用4×10¹³ n/cm²/s的热中子通量辐照天然Lu₂O₃样品，获得了比活度为2.6 - 3 GBq/mg的Lu-(177)。产物转化为氯化物形式，进而成功用于标记放射性化学纯度高（>99.9%，即时薄层色谱法，甲醇:水:乙酸，4:4:2，作为流动相）的Lu(-177)植酸盐络合物。在最终溶液中检查络合物稳定性和粘度长达7天。将制备的络合物溶液（100 μCi/100 μl）关节内注射到雄性大鼠膝关节。研究注射部位放射性泄漏及其在器官中的分布长达7天。注射后7天，几乎所有注射剂量都留在注射部位。该络合物被证明是肿瘤学和风湿病中空腔放射治疗的可行药物。