Im Hyung-Jun, Kim Yong-Il, Kim Woo Ho, Kim Seung Hyup, Kang Keon Wook
Department of Nuclear Medicine, Seoul National University College of Medicine, 28, Yeongeon-dong, Jongno-gu, Seoul, 110-799 South Korea.
Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea.
Nucl Med Mol Imaging. 2011 Jun;45(2):139-44. doi: 10.1007/s13139-010-0071-7. Epub 2011 Jan 6.
The expression of glucose transporters (Glut-1, Glut-3), hexokinase-II, and Ki-67 has been proposed to explain intratumoral heterogeneous F-18 fluorodeoxyglucose (FDG) uptake. We report a case of Krukenberg tumor with intratumoral heterogeneous FDG uptake which corresponded well with the expression levels of Glut-1 and ki-67. Fused positron emission tomography (PET)/magnetic resonance (MR) imaging was helpful for localizing the metabolically active area in the tumor specimen. This report elucidates the relationship between the intratumoral heterogeneous FDG uptake and biologic heterogeneity, and shows the usefulness of PET/MR in research on intratumoral heterogeneity.
葡萄糖转运蛋白（Glut-1、Glut-3）、己糖激酶-II和Ki-67的表达已被提出用于解释肿瘤内异质性F-18氟脱氧葡萄糖（FDG）摄取。我们报告一例具有肿瘤内异质性FDG摄取的库肯勃瘤病例，其与Glut-1和Ki-67的表达水平高度相符。正电子发射断层显像（PET）/磁共振（MR）融合成像有助于在肿瘤标本中定位代谢活跃区域。本报告阐明了肿瘤内异质性FDG摄取与生物学异质性之间的关系，并显示了PET/MR在肿瘤内异质性研究中的实用性。
