Chang Shen-Shong, Hu Hsiao-Yun
Hepatogastroenterology. 2014 Mar-Apr;61(130):529-34.
BACKGROUND/AIMS: Inverse correlation between childhood-onset asthma and human gastric Helicobacter pylori (H. pylori) infection exists. To investigate whether adult asthma patients with peptic ulcer disease demonstrated lower rates of H. pylori infection.
Asthma patients were identified from records of inpatient treatments or from 3 or more ambulatory care claims using the International Classifications of Diseases, Revision 9, Clinical Modification (ICD-9-CM) diagnosis code: 493. To be defined as a non-asthma patient, a person cannot have the code ICD-9-CM: 490-494, and 496 in inpatient records or in the ambulatory care claims. The sample included 2,894 H. pylori-positive patients with peptic ulcers and 522 H. pylori-negative patients with peptic ulcers. A logistic regression model was used to calculate the odds ratio and a 95% confidence interval.
Asthma patients with peptic ulcers included 74 H. pylori-positive and 21 H. pylori-negative. Non-asthma patients with peptic ulcers comprised 2,820 H. pylori-positive and 501 H. pylori-negative. Based on logistic regression analysis, adult asthma patients with peptic ulcers (OR = 0.71, P = 0.187) demonstrated similar H. pylori infection rates, compared to adult non-asthma patients with peptic ulcers.
Our data show no inverse relationship between Helicobacter pylori infection and adult asthma with peptic ulcers.
背景/目的：儿童期哮喘与人类胃幽门螺杆菌（H. pylori）感染之间存在负相关。本研究旨在调查患有消化性溃疡疾病的成年哮喘患者幽门螺杆菌感染率是否较低。
通过国际疾病分类第9版临床修订本（ICD - 9 - CM）诊断代码493，从住院治疗记录或3次及以上门诊护理索赔记录中识别哮喘患者。若一个人在住院记录或门诊护理索赔中没有ICD - 9 - CM代码490 - 494和496，则被定义为非哮喘患者。样本包括2894例幽门螺杆菌阳性的消化性溃疡患者和522例幽门螺杆菌阴性的消化性溃疡患者。使用逻辑回归模型计算比值比和95%置信区间。
患有消化性溃疡的哮喘患者中，74例幽门螺杆菌阳性，21例幽门螺杆菌阴性。患有消化性溃疡的非哮喘患者中，2820例幽门螺杆菌阳性，501例幽门螺杆菌阴性。基于逻辑回归分析，患有消化性溃疡的成年哮喘患者（OR = 0.71，P = 0.187）与患有消化性溃疡的成年非哮喘患者相比，幽门螺杆菌感染率相似。
我们的数据表明幽门螺杆菌感染与患有消化性溃疡的成年哮喘之间不存在负相关关系。
