Department of Obstetrics and Gynecology, University of Illinois at Chicago, and the University of Illinois at Chicago School of Public Health, Chicago, Illinois.
Obstet Gynecol. 2014 Jul;124(1):76-81. doi: 10.1097/AOG.0000000000000319.
"Catch-up vaccination" is vaccination outside of the recommended schedule and may occur between 13 and 26 years of age for human papillomavirus vaccines. We aimed to characterize those adolescents and young women who were most likely to complete the three-vaccine series on a catch-up schedule.
We performed a retrospective review of adolescents and young women aged 13-26 years who initiated human papillomavirus vaccination between January 2007 and April 2009 and followed them through April 2010 for vaccine completion (n=310). Completion was defined as receipt of three doses of the human papillomavirus vaccine. We used log binomial regression to investigate characteristics associated with vaccine completion. The main exposure was pregnancy occurring within 1 year of initiating the series. Other exposure variables included age, race, insurance, and clinical site.
Fifty-six percent of participants completed the vaccine series with a mean follow-up of 2 years. After adjusting for age and site of vaccination, those who became pregnant (n=31) were significantly less likely than those who did not to complete the series (22.6% compared with 59.9%, respectively, adjusted relative risk 0.42, 95% confidence interval [CI] 0.21-0.81). Race or ethnicity was also independently associated with completion, with black patients having the lowest completion rate (48% compared with 72.1% among white patients, adjusted relative risk 0.71, 95% CI 0.54-0.91).
Human papillomavirus vaccination completion is low among adolescents and females receiving vaccination on a catch-up schedule. Those who become pregnant may not resume the series after pregnancy. Vaccine initiation is an opportunity for contraceptive provision for adolescents and young women.
: II.
“补种疫苗”是指在推荐的接种时间表之外进行的疫苗接种，对于人乳头瘤病毒疫苗，可能发生在 13 至 26 岁之间。我们旨在确定最有可能按照补种时间表完成三剂系列疫苗接种的青少年和年轻女性。
我们对 2007 年 1 月至 2009 年 4 月期间开始接种人乳头瘤病毒疫苗且在 2010 年 4 月前接受疫苗接种完成随访的 13-26 岁青少年和年轻女性（n=310）进行了回顾性研究。完成定义为接受三剂人乳头瘤病毒疫苗。我们使用对数二项式回归来研究与疫苗完成相关的特征。主要暴露是在开始接种系列疫苗一年内怀孕。其他暴露变量包括年龄、种族、保险和临床地点。
56%的参与者完成了疫苗系列接种，平均随访时间为 2 年。在调整年龄和接种地点后，与未完成系列接种的人相比，怀孕的人（n=31）完成系列接种的可能性明显较低（分别为 22.6%和 59.9%，调整后的相对风险 0.42，95%置信区间 [CI] 0.21-0.81）。种族或族裔也与完成情况独立相关，黑人患者的完成率最低（48%，而白人患者为 72.1%，调整后的相对风险 0.71，95%CI 0.54-0.91）。
在接受补种时间表接种疫苗的青少年和女性中，人乳头瘤病毒疫苗接种完成率较低。怀孕的人在怀孕后可能不会恢复接种系列。疫苗接种启动是为青少年和年轻女性提供避孕措施的机会。
II。
