电休克治疗中的图像：电休克剂量依赖性地增加大鼠海马体CA1区的树突分支。

Images in electroconvulsive therapy: electroconvulsive shocks dose-dependently increase dendritic arborization in the CA1 region of the rat hippocampus.

作者信息

Smitha Jangama S M, Roopa Ravindranath, Khaleel Nagarchi, Kutty Bindu M, Andrade Chittaranjan

机构信息

From the *Department of Anatomy, St John's Medical College; and Departments of †Neurophysiology and ‡Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, India.

出版信息

J ECT. 2014 Sep;30(3):191-2. doi: 10.1097/YCT.0000000000000077.

DOI:10.1097/YCT.0000000000000077

PMID:24901430

Abstract

Stress and depression are associated with impaired neuroplasticity in the hippocampus: there is decreased dendritic arborization and synaptogenesis, which is hypothesized to explain decreased adaptive competence of the organism. Representative light microscopy images are presented that show that 6 once-daily electroconvulsive shocks (ECSs) dose-dependently increased dendritic arborization in the CA1 region of the hippocampus in healthy, adult, male Wistar rats (n = 10 in each of sham, 10-mC, and 40-mC ECS groups). These neuroplasticity changes, identified 1 month after the last ECS, may explain a part of the mechanism of action of electroconvulsive therapy in conditions such as depression.

摘要

应激和抑郁与海马体神经可塑性受损有关

树突分支和突触形成减少，据推测这可以解释机体适应能力的下降。呈现了代表性的光学显微镜图像，显示在健康成年雄性Wistar大鼠（假手术组、10 mC电休克组和40 mC电休克组每组n = 10）中，每天一次的6次电惊厥休克（ECS）剂量依赖性地增加了海马体CA1区的树突分支。在最后一次ECS后1个月确定的这些神经可塑性变化，可能解释了电惊厥治疗在抑郁症等病症中的部分作用机制。