Merkel细胞癌脑转移中细胞角蛋白20的缺失及甲状腺转录因子-1表达的获得
Loss of cytokeratin 20 and acquisition of thyroid transcription factor-1 expression in a merkel cell carcinoma metastasis to the brain.
作者信息
Shalin Sara C, Cifarelli Christopher P, Suen James Y, Gao Ling
机构信息
Departments of *Pathology, †Neurosurgery, ‡Otolaryngology-Head and Neck Surgery, and §Dermatology, University of Arkansas for Medical Sciences, Little Rock, AR.
出版信息
Am J Dermatopathol. 2014 Nov;36(11):904-6. doi: 10.1097/DAD.0000000000000124.
Abstract
Merkel cell carcinoma (MCC) is recognized by its morphologic features and by its classic immunophenotypic properties. Although MCCs demonstrating nonclassic immunoreactivities have been described, a case documenting a change in immunophenotype during the course of disease progression has not been previously reported. We report a case of MCC that initially demonstrated cytokeratin 20 positivity but lost expression in subsequent metastases. Likewise, thyroid transcription factor-1 was initially negative in the tumor but expression was present in metastatic lesions.
摘要
Merkel细胞癌（MCC）通过其形态学特征和经典免疫表型特性得以识别。尽管已描述了表现出非经典免疫反应性的MCC，但此前尚未报道过记录疾病进展过程中免疫表型发生变化的病例。我们报告了一例MCC，其最初表现为细胞角蛋白20阳性，但在随后的转移灶中失去了表达。同样，甲状腺转录因子-1最初在肿瘤中呈阴性，但在转移灶中出现了表达。
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