Vahedi Larijani Laleh, Ghasemi Maryam, AbedianKenari Saeid, Naghshvar Farshad
Department of Pathology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Acta Med Iran. 2014;52(3):201-5.
Most patients with gastrointestinal cancers refer to the health centers at advanced stages of the disease and conventional treatments are not significantly effective for these patients. Therefore, using modern therapeutic approaches with lower toxicity bring higher chance for successful treatment and reduced adverse effects in such patients. The aim of this study is to evaluate the effect of avocado fruit extracts on inhibition of the growth of cancer cells in comparison with normal cells. In an experimental study, ethanol, chloroform, ethyl acetate, and petroleum extracts of avocado (Persea americana) fruit were prepared. Then, the effects if the extracts on the growth of esophageal squamous cell carcinoma and colon adenocarcinoma cell lines were evaluated in comparison with the control group using the MTT test in the cell culture medium. Effects of the four extracts of avocado fruit on three cells lines of peripheral blood mononuclear cells, esophageal squamous cell carcinoma, and colon adenocarcinoma were tested. The results showed that avocado fruit extract is effective in inhibition of cancer cell growth in comparison with normal cells (P<0.05). Avocado fruit is rich in phytochemicals, which play an important role in inhibition of growth of cancer cells. The current study for the first time demonstrates the anti-cancer effect of avocado fruit extracts on two cancers common in Iran. Therefore, it is suggested that the fruit extracts can be considered as appropriate complementary treatments in treatment of esophageal and colon cancers.
大多数胃肠道癌症患者在疾病晚期才前往健康中心就诊，传统治疗方法对这些患者效果并不显著。因此，采用毒性较低的现代治疗方法能为这类患者带来更高的成功治疗几率，并减少不良反应。本研究旨在评估鳄梨果实提取物相较于正常细胞对癌细胞生长的抑制作用。在一项实验研究中，制备了鳄梨（Persea americana）果实的乙醇、氯仿、乙酸乙酯和石油提取物。然后，在细胞培养基中使用MTT试验，将提取物对食管鳞状细胞癌和结肠腺癌细胞系生长的影响与对照组进行比较。测试了鳄梨果实的四种提取物对外周血单个核细胞、食管鳞状细胞癌和结肠腺癌三种细胞系的作用。结果表明，与正常细胞相比，鳄梨果实提取物对癌细胞生长具有抑制作用（P<0.05）。鳄梨果实富含植物化学物质，这些物质在抑制癌细胞生长中发挥着重要作用。本研究首次证明了鳄梨果实提取物对伊朗常见的两种癌症具有抗癌作用。因此，建议果实提取物可被视为治疗食管癌和结肠癌的合适辅助治疗方法。
