Shiraishi Atsushi, Yamaguchi Masahiko, Ohashi Yuichi
Departments of Ophthalmology (A.S., M.Y., Y.O.), Stem Cell Biology (A.S.), and Infectious Diseases (Y.O.), Ehime University Graduate School of Medicine, Toon, Japan.
Eye Contact Lens. 2014 Jul;40(4):220-4. doi: 10.1097/ICL.0000000000000040.
To report lid-wiper epitheliopathy (LWE)-like staining at the lower eyelid margin (lower-LWE) and to determine the prevalence of LWE (upper-LWE) and lower-LWE in contact lens (CL) wearers and non-CL wearers.
Four hundred forty-three eyes of 229 non-CL wearers, 405 eyes of 208 soft CL wearers, and 135 eyes of 71 rigid gas permeable CL wearers were studied. Lissamine green and fluorescein (FL) staining were used to assess the degree of LWEs, tear break-up time (BUT), and cornea-conjunctival staining (FL-S). The correlations between the prevalence of LWEs and the other factors were evaluated.
The prevalence of lower-LWE was significantly higher (39.5%) than upper-LWE in non-CL wearers (upper-LWE; 12.0%; P<0.001). The prevalence of both upper- and lower-LWE were significantly correlated with age and FL-S, but not sex and BUT, in non-CL wearers. The prevalence of both upper- and lower-LWE was significantly higher in younger than older subjects (P<0.001). Upper- and lower-LWE were detected in a higher percentage of CL wearers than in non-CL wearers (P<0.001).
Our results indicate that examination of the lower eyelid margin would be preferable to that of the upper eyelid margin in studies of LWE.
报告下睑缘类似擦睑缘上皮病变（LWE）的染色情况，并确定接触镜（CL）佩戴者和非CL佩戴者中LWE（上睑LWE）和下睑LWE的患病率。
对229名非CL佩戴者的443只眼、208名软性CL佩戴者的405只眼和71名硬性透气性CL佩戴者的135只眼进行了研究。使用丽丝胺绿和荧光素（FL）染色来评估LWE的程度、泪膜破裂时间（BUT）和角膜结膜染色（FL-S）。评估了LWE患病率与其他因素之间的相关性。
在非CL佩戴者中，下睑LWE的患病率（39.5%）显著高于上睑LWE（上睑LWE；12.0%；P<0.001）。在非CL佩戴者中，上睑和下睑LWE的患病率均与年龄和FL-S显著相关，但与性别和BUT无关。年轻受试者中上睑和下睑LWE的患病率均显著高于年长受试者（P<0.001）。CL佩戴者中上睑和下睑LWE的检出率高于非CL佩戴者（P<0.001）。
我们的结果表明，在LWE研究中，检查下睑缘比检查上睑缘更可取。
