Satoh M, Kaya K, Yamanaka I, Kasama A, Yanagisawa M
Tohoku J Exp Med. 1978 Jan;124(1):65-72. doi: 10.1620/tjem.124.65.
In aortic strips, the dose-response curves for phenylephrine were obtained before and after addition of droperidol. Droperidol caused a parallel shift of the curves dose-dependently toward the right side and its grade of the shift was greater than caused by phentolamine at the same concentration. In the left atrial strip, the potentiation of contraction by tyramine was markedly depressed by droperidol. In the reserpinized preparation, the effect of tyramine was depressed markedly and there was no norepinephrine fluorescence. After incubation with norepinephrine they were restored to the same level as in non-reserpinized preparations. However, incubation with droperidol before norepinephrine blocked the restoration. It is postulated that droperidol may have both alpha-adrenergic blocking action and inhibitory action on norepinephrine uptake by adrenergic terminals.
在主动脉条中，在添加氟哌利多前后获得去氧肾上腺素的剂量-反应曲线。氟哌利多使曲线剂量依赖性地平行向右移动，且其移动程度大于相同浓度酚妥拉明引起的移动。在左心房条中，氟哌利多显著抑制酪胺引起的收缩增强。在利血平化的制剂中，酪胺的作用显著降低且无去甲肾上腺素荧光。用去甲肾上腺素孵育后，它们恢复到与未利血平化制剂相同的水平。然而，在去甲肾上腺素之前用氟哌利多孵育可阻断这种恢复。据推测，氟哌利多可能既有α-肾上腺素能阻断作用，又有对肾上腺素能末梢摄取去甲肾上腺素的抑制作用。
