Healy David, Howe Gareth, Mangin Derelie, Le Noury Joanna
North Wales Department of Psychological Medicine, Bangor, Wales, UK.
David Braley & Nancy Gordon Chair of Family Medicine, Department of Family Medicine, McMaster University, Hamilton, Canada.
Int J Risk Saf Med. 2014;26(2):71-9. doi: 10.3233/JRS-140615.
Adverse effects of treatment on cardiac QT intervals were first reported 50 years ago. A clear link to sudden death was established, but the problem remained relatively unknown. The issue of treatment related effects on the heart, and the contribution this might make to sudden cardiac deaths in general, came more clearly into focus 20 years ago, linked to regulatory actions. In an era of polypharmacy, and mixing of prescribed and non-prescribed pharmacologically active agents it is now becoming increasingly clear that unanticipated cardiac effects may be common and a significant cause of mortality. There is likely underreporting and also underdiagnosis, as recognition requires a timely ECG. This paper proposes two methods to handle the problem.
治疗对心脏QT间期的不良影响早在50年前就有报道。虽然已确定其与猝死之间存在明确联系，但该问题仍相对鲜为人知。20年前，与监管行动相关，治疗对心脏的相关影响以及这可能对一般心脏性猝死造成的影响这一问题，才更加清晰地成为焦点。在一个多种药物并用、处方药与非处方药的药理活性成分相互混杂的时代，现在越来越清楚的是，意料之外的心脏影响可能很常见，并且是一个重要的死亡原因。由于需要及时进行心电图检查才能确诊，所以可能存在报告不足和诊断不足的情况。本文提出了两种方法来处理该问题。
