Hu Shudong, Huang Wei, Chen Yerong, Song Qi, Lin Xiaozhu, Wang Zhongmin, Chen Kemin
Department of Radiology, The Affiliated Renmin Hospital, Jiangsu University, Zhenjiang, Jiangsu, 212002, China,
Eur Radiol. 2014 Sep;24(9):2167-73. doi: 10.1007/s00330-014-3257-z. Epub 2014 Jun 6.
We sought to evaluate the capability of spectral CT to detect the therapeutic response to (125)I interstitial brachytherapy in a pancreatic carcinoma xenograft nude mouse model.
Twenty mice bearing SWl990 human pancreatic cancer cell xenografts were randomly separated into two groups: experimental (n = 10; 1.0 mCi) and control (n = 10; 0 mCi). After a two-week treatment, spectral CT was performed. Contrast-to-noise ratio (CNR) and iodine concentration (IC) in the lesions were measured and normalized to the muscle tissue, and nIC CD31 immunohistochemistry was used to measure microvessel density (MVD). The relationships between the nIC and MVD of the tumours were analysed.
The nIC of the experimental group was significantly lower than that of the control group during the multiphase examination. A significant difference in the MVD was observed between the two groups (P <0.001). The nIC values of the three-phase scans have a certain positive correlation with MVD (r = 0.57, p < 0.0001; r = 0.48, p = 0.002; r = 0.63, p = 0.0017 in the 10, 25, and 60 s phase, respectively).
Spectral CT can be a useful non-invasive imaging modality in evaluating the therapeutic effect of (125)I interstitial brachytherapy to a pancreatic carcinoma.
Spectral CT offers opportunities to assess therapeutic response in pancreatic cancer cases. Spectral CT findings correlated with vascular changes associated with (125)I seed implantation. Spectral CT with monochromatic imaging removed most (125)I seed artefacts.
我们试图在胰腺癌异种移植裸鼠模型中评估光谱CT检测对¹²⁵I组织间近距离放射治疗的治疗反应的能力。
将20只携带SW1990人胰腺癌细胞异种移植瘤的小鼠随机分为两组：实验组（n = 10；1.0毫居里）和对照组（n = 10；0毫居里）。经过两周治疗后，进行光谱CT检查。测量病变中的对比噪声比（CNR）和碘浓度（IC），并将其相对于肌肉组织进行标准化，采用nIC CD31免疫组织化学法测量微血管密度（MVD）。分析肿瘤的nIC与MVD之间的关系。
在多期检查期间，实验组的nIC显著低于对照组。两组之间的MVD观察到显著差异（P<0.001）。三相扫描的nIC值与MVD有一定的正相关性（在10、25和60秒时相，r分别为0.57，p<0.0001；r = 0.48，p = 0.002；r = 0.63，p = 0.0017）。
光谱CT在评估¹²⁵I组织间近距离放射治疗对胰腺癌的治疗效果方面可能是一种有用的非侵入性成像方式。
光谱CT为评估胰腺癌病例的治疗反应提供了机会。光谱CT结果与¹²⁵I粒子植入相关的血管变化相关。具有单色成像的光谱CT消除了大部分¹²⁵I粒子伪影。
