Angeretti A, Ferrara B, Merlino C
Istituto di Microbiologia, Università di Torino.
G Batteriol Virol Immunol. 1989 Jan-Dec;82(1-12):97-100.
In acute viral infections, specific IgM antibodies appear early and persist for a short period of time; by contrast IgG antibodies persist longer. The diagnostic significance of specific serum IgA is still discussed. We observed that in acute systemic infections, serum IgA appear early and are mainly polymeric (p-IgA) whereas monomers (m-IgA) appear in late convalescence. On the other hand, in secondary infections or in reinfections these immunoglobulins are mainly represented by monomers. In mucosa confined infections, serum IgA are almost absent suggesting that their synthesis is not related to mucosal stimulation.
在急性病毒感染中，特异性IgM抗体出现早且持续时间短；相比之下，IgG抗体持续时间更长。特异性血清IgA的诊断意义仍在讨论中。我们观察到，在急性全身感染中，血清IgA出现早且主要为多聚体（p-IgA），而单体（m-IgA）出现在恢复期后期。另一方面，在二次感染或再次感染中，这些免疫球蛋白主要以单体形式存在。在局限于黏膜的感染中，血清IgA几乎不存在，这表明它们的合成与黏膜刺激无关。
