PRDX2基因在经典型霍奇金淋巴瘤的霍奇金和里德-斯腾伯格细胞中发生转录沉默和从头甲基化。 - Suppr

The PRDX2 gene is transcriptionally silenced and de novo methylated in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma.

作者信息

Schneider Markus, Szaumkessel Marcin, Richter Julia, Ammerpohl Ole, Hansmann Martin-Leo, Küppers Ralf, Siebert Reiner, Giefing Maciej

机构信息

University of Duisburg-Essen, Essen, Germany.

Polish Academy of Sciences, Poznań, Poland.

出版信息

Blood. 2014 Jun 5;123(23):3672-4. doi: 10.1182/blood-2014-02-553263.

DOI:10.1182/blood-2014-02-553263

PMID:24904103

Abstract

摘要

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The PRDX2 gene is transcriptionally silenced and de novo methylated in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma.PRDX2基因在经典型霍奇金淋巴瘤的霍奇金和里德-斯腾伯格细胞中发生转录沉默和从头甲基化。

Blood. 2014 Jun 5;123(23):3672-4. doi: 10.1182/blood-2014-02-553263.

Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene.全基因组分析 AML 中组蛋白 H3 乙酰化模式，鉴定 PRDX2 为受表观遗传沉默的抑癌基因。

Blood. 2012 Mar 8;119(10):2346-57. doi: 10.1182/blood-2011-06-358705. Epub 2011 Dec 29.

Tumor-specific methylation of the 8p22 tumor suppressor gene DLC1 is an epigenetic biomarker for Hodgkin, nasal NK/T-cell and other types of lymphomas.8p22肿瘤抑制基因DLC1的肿瘤特异性甲基化是霍奇金淋巴瘤、鼻NK/T细胞淋巴瘤及其他类型淋巴瘤的一种表观遗传生物标志物。

Epigenetics. 2007 Jan-Mar;2(1):15-21. doi: 10.4161/epi.2.1.3883. Epub 2007 Jan 15.

Epigenetic silencing of the tumor suppressor genes SPI1, PRDX2, KLF4, DLEC1, and DAPK1 in childhood and adolescent lymphomas.儿童和青少年淋巴瘤中肿瘤抑制基因SPI1、PRDX2、KLF4、DLEC1和DAPK1的表观遗传沉默

Pediatr Hematol Oncol. 2018 Mar;35(2):131-144. doi: 10.1080/08880018.2018.1467986. Epub 2018 Jul 18.

Detection of genomic imbalances in microdissected Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma by array-based comparative genomic hybridization.通过基于芯片的比较基因组杂交技术检测经典型霍奇金淋巴瘤显微切割的霍奇金和里德-斯腾伯格细胞中的基因组失衡

Haematologica. 2008 Sep;93(9):1318-26. doi: 10.3324/haematol.12875. Epub 2008 Jul 18.

Non-invasive detection of genomic imbalances in Hodgkin/Reed-Sternberg cells in early and advanced stage Hodgkin's lymphoma by sequencing of circulating cell-free DNA: a technical proof-of-principle study.通过循环游离DNA测序对早期和晚期霍奇金淋巴瘤中霍奇金/里德-斯腾伯格细胞的基因组失衡进行无创检测：一项原理验证技术研究。

Lancet Haematol. 2015 Feb;2(2):e55-65. doi: 10.1016/S2352-3026(14)00039-8. Epub 2015 Jan 20.

Patterned CpG methylation of silenced B cell gene promoters in classical Hodgkin lymphoma-derived and primary effusion lymphoma cell lines.经典型霍奇金淋巴瘤衍生细胞系和原发性渗出性淋巴瘤细胞系中沉默的B细胞基因启动子的模式化CpG甲基化

J Mol Biol. 2005 Jul 22;350(4):631-40. doi: 10.1016/j.jmb.2005.05.032.

Immunoglobulin gene rearrangement analysis in composite hodgkin disease and large B-cell lymphoma: evidence for receptor revision of immunoglobulin heavy chain variable region genes in Hodgkin-Reed-Sternberg cells?复合性霍奇金淋巴瘤和大B细胞淋巴瘤中的免疫球蛋白基因重排分析：霍奇金-里德-斯腾伯格细胞中免疫球蛋白重链可变区基因受体修正的证据？

Diagn Mol Pathol. 2002 Mar;11(1):2-8. doi: 10.1097/00019606-200203000-00002.

Diminished expression of 5hmc in Reed-Sternberg cells in classical Hodgkin lymphoma is a common epigenetic marker.经典型霍奇金淋巴瘤中 Reed-Sternberg 细胞中 5hmc 的表达减少是一种常见的表观遗传标记。

Leuk Res. 2020 Sep;96:106408. doi: 10.1016/j.leukres.2020.106408. Epub 2020 Jul 2.

Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma.霍奇金里德-斯腾伯格细胞表达15-脂氧合酶-1，是体内环氧二十碳三烯酸的假定产生者：对经典型霍奇金淋巴瘤炎症特征的新见解。

FEBS J. 2008 Aug;275(16):4222-34. doi: 10.1111/j.1742-4658.2008.06570.x. Epub 2008 Jul 18.

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The Tumor Suppressive mir-148a Is Epigenetically Inactivated in Classical Hodgkin Lymphoma.抑癌基因 mir-148a 在经典型霍奇金淋巴瘤中被表观遗传失活。

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Antioxidants (Basel). 2018 Nov 11;7(11):161. doi: 10.3390/antiox7110161.

Peroxiredoxin II Regulates Cancer Stem Cells and Stemness-Associated Properties of Cancers.过氧化物还原酶II调节癌症干细胞及癌症的干性相关特性。

Cancers (Basel). 2018 Sep 3;10(9):305. doi: 10.3390/cancers10090305.

Preconditioning by Hydrogen Peroxide Enhances Multiple Properties of Human Mesenchymal Stem/Multipotent Stromal Cells.过氧化氢预处理可增强人间充质干细胞/多能基质细胞的多种特性。

Stem Cells Int. 2018 Apr 29;2018:6480793. doi: 10.1155/2018/6480793. eCollection 2018.

Silencing of peroxiredoxin II by promoter methylation is necessary for the survival and migration of gastric cancer cells.启动子甲基化沉默过氧化物还原酶 II 是胃癌细胞存活和迁移所必需的。

Exp Mol Med. 2018 Feb 9;50(2):e443. doi: 10.1038/emm.2017.267.

Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells.端锚聚合酶与过氧化物酶体增殖物激活受体II的相互作用对结肠癌细胞的存活至关重要。

Nat Commun. 2017 Jun 28;8(1):40. doi: 10.1038/s41467-017-00054-0.

Epigenetic regulation of peroxiredoxins: Implications in the pathogenesis of cancer.过氧化物氧还蛋白的表观遗传调控：对癌症发病机制的影响

Exp Biol Med (Maywood). 2017 Jan;242(2):140-147. doi: 10.1177/1535370216669834. Epub 2016 Oct 4.

SEPTIN2 and STATHMIN Regulate CD99-Mediated Cellular Differentiation in Hodgkin's Lymphoma.SEPTIN2和STATHMIN调节霍奇金淋巴瘤中CD99介导的细胞分化。

PLoS One. 2015 May 22;10(5):e0127568. doi: 10.1371/journal.pone.0127568. eCollection 2015.

CBFB-MYH11 hypomethylation signature and PBX3 differential methylation revealed by targeted bisulfite sequencing in patients with acute myeloid leukemia.靶向亚硫酸氢盐测序揭示急性髓系白血病患者的CBFB-MYH11低甲基化特征及PBX3差异甲基化

J Hematol Oncol. 2014 Sep 30;7:66. doi: 10.1186/s13045-014-0066-4.

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The PRDX2 gene is transcriptionally silenced and de novo methylated in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma.

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