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The PRDX2 gene is transcriptionally silenced and de novo methylated in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma.

作者信息

Schneider Markus, Szaumkessel Marcin, Richter Julia, Ammerpohl Ole, Hansmann Martin-Leo, Küppers Ralf, Siebert Reiner, Giefing Maciej

机构信息

University of Duisburg-Essen, Essen, Germany.

Polish Academy of Sciences, Poznań, Poland.

出版信息

Blood. 2014 Jun 5;123(23):3672-4. doi: 10.1182/blood-2014-02-553263.

DOI:10.1182/blood-2014-02-553263
PMID:24904103
Abstract
摘要

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The PRDX2 gene is transcriptionally silenced and de novo methylated in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma.PRDX2基因在经典型霍奇金淋巴瘤的霍奇金和里德-斯腾伯格细胞中发生转录沉默和从头甲基化。
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Detection of genomic imbalances in microdissected Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma by array-based comparative genomic hybridization.通过基于芯片的比较基因组杂交技术检测经典型霍奇金淋巴瘤显微切割的霍奇金和里德-斯腾伯格细胞中的基因组失衡
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Patterned CpG methylation of silenced B cell gene promoters in classical Hodgkin lymphoma-derived and primary effusion lymphoma cell lines.经典型霍奇金淋巴瘤衍生细胞系和原发性渗出性淋巴瘤细胞系中沉默的B细胞基因启动子的模式化CpG甲基化
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Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma.霍奇金里德-斯腾伯格细胞表达15-脂氧合酶-1，是体内环氧二十碳三烯酸的假定产生者：对经典型霍奇金淋巴瘤炎症特征的新见解。
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Antioxidants (Basel). 2018 Nov 11;7(11):161. doi: 10.3390/antiox7110161.
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