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ETV6 and signaling gene mutations are associated with secondary transformation of myelodysplastic syndromes to chronic myelomonocytic leukemia.

作者信息

Padron Eric, Yoder Sean, Kunigal Sateesh, Mesa Tania, Teer Jamie K, Al Ali Najla, Sekeres Mikkael A, Painter Jeffrey S, Zhang Ling, Lancet Jeffrey, Maciejewski Jaroslaw P, Epling-Burnette Pearlie K, Sotomayor Eduardo, Komrokji Rami S, List Alan F

机构信息

Department of Hematologic Malignancies, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FLImmunology Program, H. Lee Moffitt Cancer Center and Research Institute, and the University of South Florida, Tampa, FL.

Molecular Genomics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

出版信息

Blood. 2014 Jun 5;123(23):3675-7. doi: 10.1182/blood-2014-03-562637.

DOI:10.1182/blood-2014-03-562637
PMID:24904105
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4047502/
Abstract
摘要

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ETV6 and signaling gene mutations are associated with secondary transformation of myelodysplastic syndromes to chronic myelomonocytic leukemia.ETV6与信号基因变异与骨髓增生异常综合征向慢性粒单核细胞白血病的二次转化相关。
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Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia.多梳蛋白相关基因ASXL1在骨髓增生异常综合征和急性髓系白血病中频繁发生突变。
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Mutated and number of somatic mutations as possible indicators of progression to chronic myelomonocytic leukemia of myelodysplastic syndromes with single or multilineage dysplasia.作为具有单系或多系发育异常的骨髓增生异常综合征进展为慢性粒单核细胞白血病的可能指标的体细胞突变及突变数量。
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本文引用的文献

1
Landscape of genetic lesions in 944 patients with myelodysplastic syndromes.944例骨髓增生异常综合征患者的基因损伤图谱
Leukemia. 2014 Feb;28(2):241-7. doi: 10.1038/leu.2013.336. Epub 2013 Nov 13.
2
Clinical and biological implications of driver mutations in myelodysplastic syndromes.骨髓增生异常综合征中驱动突变的临床和生物学意义。
Blood. 2013 Nov 21;122(22):3616-27; quiz 3699. doi: 10.1182/blood-2013-08-518886. Epub 2013 Sep 12.
3
Clonal architecture of chronic myelomonocytic leukemias.慢性粒单核细胞白血病的克隆结构。
Blood. 2013 Mar 21;121(12):2186-98. doi: 10.1182/blood-2012-06-440347. Epub 2013 Jan 14.
4
Frequent pathway mutations of splicing machinery in myelodysplasia.骨髓增生异常综合征中剪接机制的频繁通路突变。
Nature. 2011 Sep 11;478(7367):64-9. doi: 10.1038/nature10496.
5
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.突变型C-CBL肿瘤抑制因子在髓系肿瘤中的功能获得
Nature. 2009 Aug 13;460(7257):904-8. doi: 10.1038/nature08240. Epub 2009 Jul 20.
6
AML1 mutations induced MDS and MDS/AML in a mouse BMT model.在小鼠骨髓移植模型中，AML1突变诱发了骨髓增生异常综合征（MDS）和MDS/急性髓系白血病（AML）。
Blood. 2008 Apr 15;111(8):4297-308. doi: 10.1182/blood-2007-01-068346. Epub 2008 Jan 11.
7
Chronic myelomonocytic leukemia evolving from preexisting myelodysplasia shares many features with de novo disease.由先前存在的骨髓发育异常演变而来的慢性粒单核细胞白血病与原发性疾病有许多共同特征。
Am J Clin Pathol. 2006 Nov;126(5):789-97. doi: 10.1309/FU04-P779-U310-R3EE.
8
Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice.致癌性NRAS可在小鼠中快速有效地诱发CMML样和AML样疾病。
Blood. 2006 Oct 1;108(7):2349-57. doi: 10.1182/blood-2004-08-009498. Epub 2006 Jun 8.