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A major hindrance in antibody affinity maturation investigation: we never succeeded in falsifying the hypothesis of single-step selection.

作者信息

Or-Guil Michal, Faro Jose

机构信息

Systems Immunology Laboratory, Department of Biology, Humboldt-Universität zu Berlin , Berlin , Germany ; Research Center ImmunoSciences, Charité-Universitätsmedizin Berlin , Berlin , Germany.

Area of Immunology, Faculty of Biology, Biomedical Research Center (CINBIO), Universidade de Vigo , Vigo , Spain ; Instituto Biomédico de Vigo , Vigo , Spain ; Instituto Gulbenkian de Ciência , Oeiras , Portugal.

出版信息

Front Immunol. 2014 May 26;5:237. doi: 10.3389/fimmu.2014.00237. eCollection 2014.

DOI:10.3389/fimmu.2014.00237
PMID:24904585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4033600/
Abstract
摘要

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本文引用的文献

1
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Front Immunol. 2013 Sep 17;4:274. doi: 10.3389/fimmu.2013.00274. eCollection 2013.
2
How specific is too specific? B-cell responses to viral infections reveal the importance of breadth over depth.过于具体是否合适？B 细胞对病毒感染的反应揭示了广度胜于深度的重要性。
Immunol Rev. 2013 Sep;255(1):82-94. doi: 10.1111/imr.12094.
3
How oligoclonal are germinal centers? A new method for estimating clonal diversity from immunohistological sections.
生发中心的寡克隆程度如何？一种从免疫组化切片中估计克隆多样性的新方法。
BMC Bioinformatics. 2013;14 Suppl 6(Suppl 6):S8. doi: 10.1186/1471-2105-14-S6-S8. Epub 2013 Apr 17.
4
A one-shot germinal center model under protein structural stability constraints.在蛋白质结构稳定性限制下的单次生发中心模型。
Phys Biol. 2013 Apr;10(2):025001. doi: 10.1088/1478-3975/10/2/025001. Epub 2013 Mar 15.
5
Is there a typical germinal center? A large-scale immunohistological study on the cellular composition of germinal centers during the hapten-carrier-driven primary immune response in mice.是否存在典型的生发中心？在小鼠半抗原-载体驱动的初次免疫反应中，对生发中心细胞组成的大规模免疫组织化学研究。
J Immunol. 2011 Dec 15;187(12):6185-96. doi: 10.4049/jimmunol.1101440. Epub 2011 Nov 18.
6
Rep-Seq: uncovering the immunological repertoire through next-generation sequencing.重测序：通过下一代测序技术揭示免疫受体库。
Immunology. 2012 Mar;135(3):183-91. doi: 10.1111/j.1365-2567.2011.03527.x.
7
Affinity maturation of B cells involves not only a few but a whole spectrum of relevant mutations.B 细胞的亲和力成熟不仅涉及少数相关突变，还涉及整个相关突变谱。
Int Immunol. 2011 May;23(5):345-56. doi: 10.1093/intimm/dxr018.
8
Broad volume distributions indicate nonsynchronized growth and suggest sudden collapses of germinal center B cell populations.宽体积分布表明非同步生长，并提示生发中心 B 细胞群体的突然崩溃。
J Immunol. 2010 Feb 1;184(3):1339-47. doi: 10.4049/jimmunol.0901040. Epub 2010 Jan 6.
9
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J Theor Biol. 2008 Nov 21;255(2):210-22. doi: 10.1016/j.jtbi.2008.08.005. Epub 2008 Aug 13.
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J Immunol Methods. 2008 Sep 30;338(1-2):67-74. doi: 10.1016/j.jim.2008.06.006. Epub 2008 Aug 14.