通过与放射性氯胺 - B反应测定药物制剂中的异烟肼。
Determination of isoniazid in pharmaceutical preparations by reaction with radiochloramine-B.
作者信息
Subhashini M, Subramanian M S, Rao V R
机构信息
Department of Chemistry, Indian Institute of Technology, Madras.
出版信息
J Pharm Biomed Anal. 1989;7(12):1473-7. doi: 10.1016/0731-7085(89)80153-0.
PMID:2490531
Abstract
A method has been developed for the determination of isoniazid (INH) at microgram level in pharmaceutical preparations based on the oxidation of isoniazid by radiochloramine-B. Interference of vitamin C has been overcome by precipitation as lead ascorbate and that of rifampicin and p-aminosalicylic acid by selective extraction. Amounts as low as 25 micrograms of INH can be determined.
摘要
已开发出一种基于放射性氯胺 - B氧化异烟肼来测定药物制剂中微克级异烟肼（INH）的方法。通过将维生素C沉淀为抗坏血酸铅克服了其干扰，通过选择性萃取克服了利福平及对氨基水杨酸的干扰。可测定低至25微克的异烟肼含量。
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